Tang, Yan and Benusiglio, Diego and Lefevre, Arthur and Hilfiger, Louis and Althammer, Ferdinand and Bludau, Anna and Hagiwara, Daisuke and Baudon, Angel and Darbon, Pascal and Schimmer, Jonas and Kirchner, Matthew K. and Roy, Ranjan K. and Wang, Shiyi and Eliava, Marina and Wagner, Shlomo and Oberhuber, Martina and Conzelmann, Karl K. and Schwarz, Martin and Stern, Javier E. and Leng, Gareth and Neumann, Inga D. and Charlet, Alexandre and Grinevich, Valery (2020) Social touch promotes interfemale communication via activation of parvocellular oxytocin neurons. NATURE NEUROSCIENCE, 23 (9). 1125-+. ISSN 1097-6256, 1546-1726
Full text not available from this repository. (Request a copy)Abstract
Oxytocin (OT) is a great facilitator of social life but, although its effects on socially relevant brain regions have been extensively studied, OT neuron activity during actual social interactions remains unexplored. Most OT neurons are magnocellular neurons, which simultaneously project to the pituitary and forebrain regions involved in social behaviors. In the present study, we show that a much smaller population of OT neurons, parvocellular neurons that do not project to the pituitary but synapse onto magnocellular neurons, is preferentially activated by somatosensory stimuli. This activation is transmitted to the larger population of magnocellular neurons, which consequently show coordinated increases in their activity during social interactions between virgin female rats. Selectively activating these parvocellular neurons promotes social motivation, whereas inhibiting them reduces social interactions. Thus, parvocellular OT neurons receive particular inputs to control social behavior by coordinating the responses of the much larger population of magnocellular OT neurons. Charlet, Grinevich et al. show that social touch between female rats activates parvocellular oxytocin neurons; these neurons control social behavior by coordinating the responses of the much larger population of magnocellular oxytocin neurons.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PARAVENTRICULAR NUCLEUS; MAGNOCELLULAR NEURONS; BRAIN; RELEASE; SYSTEM; FOS; HYPOTHALAMUS; VASOPRESSIN; STIMULI; MARKERS; |
| Subjects: | 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Tierphysiologie/Neurobiologie (Prof. Dr. Inga Neumann) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 17 Mar 2021 15:46 |
| Last Modified: | 17 Mar 2021 15:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/44154 |
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