Morgenstern, Mario and Erichsen, Christoph and Militz, Matthias and Xie, Zhao and Peng, Peng Jiachen and Stannard, James and Metsemakers, Willem-Jan and Schaefer, Dirk and Alt, Volker and Soballe, Kjeld and Nerlich, Michael and Buckley, Richard E. and Blauth, Michael and Suk, Michael and Leung, Frankie and Barla, Jorge D. and Yukata, Kiminori and Qing, Bi and Kates, Stephen L. (2021) The AO trauma CPP bone infection registry: Epidemiology and outcomes ofStaphylococcus aureusbone infection. JOURNAL OF ORTHOPAEDIC RESEARCH, 39 (1). pp. 136-146. ISSN 0736-0266, 1554-527X
Full text not available from this repository. (Request a copy)Abstract
Bone infection represents a serious complication of orthopedic surgery andStaphylococcus aureusis the most common pathogen. To improve the understanding of host-pathogen interaction, we developed a biospecimen registry (AO Trauma CPP Bone Infection Registry) to collect clinical data, bacterial isolates, and serum from patients withS. aureusbone infection. A prospective multinational registry with a 12-month follow-up was created to include adult patients (18 years or older) with culture-confirmedS. aureusinfection in long bones after fracture fixation or arthroplasty. Baseline patient attributes and details on infections and treatments were recorded. Blood and serum samples were obtained at baseline, 6, and 12 months. Patient-reported outcomes were collected at 1, 6, and 12 months. Clinical outcomes were recorded. Two hundred and ninety-two patients with fracture-related infection (n = 157, 53.8%), prosthetic joint infection (n = 86, 29.5%), and osteomyelitis (n = 49, 16.8%) were enrolled. Methicillin-resistantS. aureuswas detected in 82 patients (28.4%), with the highest proportion found among patients from North American sites (n = 39, 48.8%) and the lowest from Central European sites (n = 18, 12.2%). Patient outcomes improved at 6 and 12 months in comparison to baseline. The SF-36 physical component summary mean (95% confidence interval) score, however, did not reach 50 at 12 months. The cure rate at the end of the study period was 62.1%. Although patients improved with treatment, less than two-thirds were cured in 1 year. At 12-month follow-up, patient-reported outcome scores were worse for patients with methicillin-resistantS. aureusinfections.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | OSTEOMYELITIS; MOBILITY; INDEX; SCORE; MICE; bone infection registry; fracture-related infection; MRSA; implant-related infection; Staphylococcus aureus |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Unfallchirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Feb 2022 06:32 |
| Last Modified: | 28 Feb 2022 06:32 |
| URI: | https://pred.uni-regensburg.de/id/eprint/44156 |
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