Cunha, Arthur S. and dos Santos, Luiza Vertuan and Maranon-Vasquez, Guido Artemio and Kirschneck, Christian and Gerber, Jennifer Tsi and Stuani, Maria Bernadete and Matsumoto, Mirian Aiko Nakane and Vieira, Alexandre Rezende and Scariot, Rafaela and Kuechler, Erika Calvano (2021) Genetic variants in tooth agenesis-related genes might be also involved in tooth size variations. CLINICAL ORAL INVESTIGATIONS, 25. pp. 1307-1318. ISSN 1432-6981, 1436-3771
Full text not available from this repository. (Request a copy)Abstract
Objective The present study aimed to evaluate if genetic variants in PAX9, MSX1, TGF alpha, FGF3, FGF10, FGF13, GLI2 and GLI3 are involved in TS of permanent teeth. Materials and methods Pretreatment dental records from orthodontic patients were assessed prior to recruitment. Patients with tooth agenesis and congenital anomalies (including oral cleft) and/or syndromes were excluded. Dental casts were used to measure the maximum crown dimensions of all fully erupted permanent teeth except second and third molars in mesiodistal direction. Teeth with caries, occlusal wear, mesiodistal restorations, and obvious deformities were not evaluated. Genomic DNA samples were used for genotyping. The allelic discrimination of 13 genetic variants was performed. The associations between TS and genotype were analyzed by linear regression, adjusted by gender at a significance level ofp <= 0.05. Results Genetic polymorphisms in the tooth agenesis-related genes studied here were associated with increased and decreased TS, in both maxilla and mandible (p < 0.05). Conclusion This study reported associations of novel tooth agenesis-related gene variants with permanent tooth size variations.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PAX9; MSX1; HYPODONTIA; ASSOCIATION; TGFA; IDENTIFICATION; TRANSPOSITION; DIMENSIONS; CONTRIBUTE; ANOMALIES; Polymorphism; Tooth size; Dental development |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kieferorthopädie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 14 Apr 2021 07:52 |
| Last Modified: | 14 Apr 2021 07:52 |
| URI: | https://pred.uni-regensburg.de/id/eprint/44222 |
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