Deppe, M. and Abdelnaim, M. and Hebel, T. and Kreuzer, P. M. and Poeppl, T. B. and Langguth, B. and Schecklmann, M. (2021) Concomitant lorazepam use and antidepressive efficacy of repetitive transcranial magnetic stimulation in a naturalistic setting. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, 271. pp. 61-67. ISSN 0940-1334, 1433-8491
Full text not available from this repository. (Request a copy)Abstract
Background/objectives: Repetitive transcranial magnetic stimulation (rTMS) has been established as an effective therapeutic intervention for the treatment of depression. Preliminary data suggest that the efficacy of rTMS is reduced in patients taking benzodiazepines (BZD). Here, we use real-world data from a large sample to investigate the influence of lorazepam on the effectiveness of rTMS. Methods From a retrospective cohort of clinically depressed patients that were treated with rTMS, we compared 176 patients not taking any BZD with 73 patients taking lorazepam with respect to changes in the Hamilton Depression Rating Scale (HRDS). Results Both groups improved during rTMS according to HRDS scores, but the amelioration of symptoms was significantly less pronounced in patients taking lorazepam (18% vs. 38% responders in the non-lorazepam group). We could not see any association of intake regimen of lorazepam with response in rTMS. Conclusion Our observational study suggests that intake of lorazepam impedes the response to rTMS. The impact of lorazepam and other BZD on rTMS should receive more attention and be further investigated in prospective, hypothesis-based treatment studies to determine causal relationships between medication treatments and outcome. This could lead to specific recommendations for pharmacological treatment for depressed patients undergoing rTMS.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MAJOR DEPRESSIVE DISORDER; GAMMA-AMINOBUTYRIC-ACID; RECEPTOR SUBUNIT EXPRESSION; TREATMENT-RESISTANT DEPRESSION; GABA CONCENTRATIONS; BENZODIAZEPINE USE; CORTEX GABA; THETA BURST; SAFETY; RTMS; rTMS; Brain stimulation; Depression; Affective disorder; Lorazepam; Benzodiazepine |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 14 Apr 2021 07:46 |
| Last Modified: | 14 Apr 2021 07:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/44223 |
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