Markey, Kate A. and Schluter, Jonas and Gomes, Antonio L. C. and Littmann, Eric R. and Pickard, Amanda J. and Taylor, Bradford P. and Giardina, Paul A. and Weber, Daniela and Dai, Anqi and Docampo, Melissa D. and Armijo, Gabriel K. and Slingerland, Ann E. and Slingerland, John B. and Nichols, Katherine B. and Brereton, Daniel G. and Clurman, Annelie G. and Ramos, Ruben J. and Rao, Arka and Bush, Amy and Bohannon, Lauren and Covington, Megan and Lew, Meagan V. and Rizzieri, David A. and Chao, Nelson and Maloy, Molly and Cho, Christina and Politikos, Ioannis and Giralt, Sergio and Taur, Ying and Pamer, Eric G. and Holler, Ernst and Perales, Miguel-Angel and Ponce, Doris M. and Devlin, Sean M. and Xavier, Joao and Sung, Anthony D. and Peled, Jonathan U. and Cross, Justin R. and van den Brink, Marcel R. M. (2020) The microbe-derived short-chain fatty acids butyrate and propionate are associated with protection from chronic GVHD. BLOOD, 136 (1). pp. 130-136. ISSN 0006-4971, 1528-0020
Full text not available from this repository. (Request a copy)Abstract
Studies of the relationship between the gastrointestinal microbiota and outcomes in allogeneic hematopoietic stem cell transplantation (allo-HCT) have thus far largely focused on early complications, predominantly infection and acute graft-versus-host disease (GVHD). We examined the potential relationship of the microbiome with chronic GVHD (cGVHD) by analyzing stool and plasma samples collected late after allo-HCT using a case-control study design. We found lower circulating concentrations of the microbe-derived short-chain fatty acids (SCFAs) propionate and butyrate in day 100 plasma samples from patients who developed cGVHD, compared with those who remained free of this complication, in the initial case-control cohort of transplant pa-tients and in a further cross-sectional cohort from an independent transplant center. An additional cross-sectional patient cohort from a third transplant center was analyzed; however, serum (rather than plasma) was available, and the differences in SCFAs observed in the plasma samples were not recapitulated. In sum, our findings from the primary case-control cohort and 1 of 2 cross-sectional cohorts explored suggest that the gastrointestinal microbiome may exert immuno-modulatory effects in allo-HCT patients at least in part due to control of systemic concentrations of microbe-derived SCFAs.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VERSUS-HOST-DISEASE; GUT MICROBIOME; CELL; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 18 Mar 2021 11:25 |
| Last Modified: | 18 Mar 2021 11:25 |
| URI: | https://pred.uni-regensburg.de/id/eprint/44243 |
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