Kuehlmann, Britta and Vogl, Florian D. and Kempny, Tomas and Djedovic, Gabriel and Huemer, Georg M. and Huettinger, Philipp and Tinhofer, Ines E. and Huettinger, Nina and Steinstraesser, Lars and Riml, Stefan and Waldner, Matthias and Bonham, Clark Andrew and Schenck, Thilo L. and Wechselberger, Gottfried and Haslik, Werner and Koch, Horst and Mandal, Patrick and Rab, Matthias and Pallua, Norbert and Prantl, Lukas and Larcher, Lorenz (2020) Occult Pathologic Findings in Reduction Mammaplasty in 5781 Patients-An International Multicenter Study. JOURNAL OF CLINICAL MEDICINE, 9 (7): 2223. ISSN , 2077-0383
Full text not available from this repository. (Request a copy)Abstract
Breast cancer is among the most commonly diagnosed cancers in the world, affecting one in eight women in their lifetimes. The disease places a substantial burden on healthcare systems in developed countries and often requires surgical correction. In spite of this, much of the breast cancer pathophysiology remains unknown, allowing for the cancer to develop to later stages prior to detection. Many women undergo reduction mammaplasties (RM) to adjust breast size, with over 500,000 operations being performed annually. Tissue samples from such procedures have drawn interest recently, with studies attempting to garner a better understanding of breast cancer's development. A number of samples have revealed nascent cancer developments that were previously undetected and unexpected. Investigating these so-called "occult" findings of cancer in otherwise healthy patients may provide further insight regarding risk factors and countermeasures. Here, we detail occult findings of cancer in reduction mammaplasty samples provided from a cohort of over 5000 patients from 16 different institutions in Europe. Although the majority of our resected breast tissue specimens were benign, our findings indicate that there is a continued need for histopathological examination. As a result, our study suggests that preoperative imaging should be routinely performed in patients scheduled for RM, especially those with risk factors of breast cancer, to identify and enable a primary oncologic approach.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BREAST-CANCER; WOMEN; MAMMOGRAPHY; HISTORY; RISK; reduction mammaplasty; occult breast cancer findings; international multicenter study; breast cancer screening |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Plastische-, Hand- und Wiederherstellungschirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 19 Mar 2021 08:34 |
| Last Modified: | 19 Mar 2021 08:34 |
| URI: | https://pred.uni-regensburg.de/id/eprint/44274 |
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