Ignatov, Atanas and Ortmann, Olaf (2020) Endocrine Risk Factors of Endometrial Cancer: Polycystic Ovary Syndrome, Oral Contraceptives, Infertility, Tamoxifen. CANCERS, 12 (7): 1766. ISSN 2072-6694
Full text not available from this repository. (Request a copy)Abstract
Endometrial cancer is the most common gynecologic cancer and is predominantly endocrine-related. The role of unopposed estrogen in the development of endometrial cancer has been investigated in numerous studies. Different reproductive factors such as younger age at menarche, late age at menopause, infertility, nulliparity, age of birth of the first child, and long-term use of unopposed estrogens during hormone replacement therapy have been associated with an increased risk of endometrial cancer. In contrast, there is a growing body of evidence for a protective role of oral contraceptives. Most of the published data on the association between infertility and polycystic ovary syndrome are inconclusive, whereas the effect of tamoxifen on the risk of endometrial cancer has been well established. With this review, we aim to summarize the evidence on the association between infertility, polycystic ovary syndrome, oral contraceptives, and tamoxifen and the development of endometrial cancer.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SURGICAL ADJUVANT BREAST; WOMEN; PREVENTION; endometrial cancer; PCOS; tamoxifen; infertility; oral contraceptives |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Frauenheilkunde) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 14 Apr 2021 06:53 |
| Last Modified: | 14 Apr 2021 06:53 |
| URI: | https://pred.uni-regensburg.de/id/eprint/44276 |
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