Wang, Zhijia and Huang, Ling and Yan, Yuxin and El-Zohry, Ahmed M. and Toffoletti, Antonio and Zhao, Jianzhang and Barbon, Antonio and Dick, Bernhard and Mohammed, Omar F. and Han, Gang (2020) Elucidation of the Intersystem Crossing Mechanism in a Helical BODIPY for Low-Dose Photodynamic Therapy. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 59 (37). pp. 16114-16121. ISSN 1433-7851, 1521-3773
Full text not available from this repository. (Request a copy)Abstract
Intersystem crossing (ISC) of triplet photosensitizers is a vital process for fundamental photochemistry and photodynamic therapy (PDT). Herein, we report the co-existence of efficient ISC and long triplet excited lifetime in a heavy atomfree bodipy helicene molecule. Via theoretical computation and time-resolved EPR spectroscopy, we confirmed that the ISC of the bodipy results from its twisted molecular structure and reduced symmetry. The twisted bodipy shows intense long wavelength absorption (epsilon = 1.76 x 10(5)M(-1) cm(-1) at 630 nm), satisfactory triplet quantum yield (Phi(T)= 52 %), and long-lived triplet state (T-T = 492 mu s), leading to unprecedented performance as a triplet photosensitizer for PDT. Moreover, nanoparticles constructed with such helical bodipy show efficient PDT-mediated antitumor immunity amplification with an ultra-low dose (0.25 mu g kg(-1)), which is several hundred times lower than that of the existing PDT reagents.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRIPLET EXCITED-STATE; FUSED BODIPY; PHOTOSENSITIZERS; COMPLEXES; bodipy; intersystem crossing; photodynamic therapy; photosensitizers; twisted pi-systems |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Physikalische und Theoretische Chemie > Chair of Chemistry III - Physical Chemistry (Molecular Spectroscopy and Photochemistry) > Prof. Dr. Bernhard Dick |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 19 Mar 2021 13:35 |
| Last Modified: | 19 Mar 2021 13:35 |
| URI: | https://pred.uni-regensburg.de/id/eprint/44336 |
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