Balduzzi, Adriana and Boenig, Halvard and Jaerisch, Andrea and Nava, Tiago and Ansari, Marc and Cattoni, Alessandro and Prunotto, Giulia and Lucchini, Giovanna and Krivan, Gergely and Matic, Toni and Kalwak, Krzyzstof and Yesilipek, Akif and Ifversen, Marianne and Svec, Peter and Buechner, Jochen and Vettenranta, Kim and Meisel, Roland and Lawitschka, Anita and Peters, Christina and Gibson, Brenda and Dalissier, Arnaud and Corbacioglu, Selim and Willasch, Andre and Dalle, Jean-Hugues and Bader, Peter (2021) ABO incompatibile graft management in pediatric transplantation. BONE MARROW TRANSPLANTATION, 56 (1). pp. 84-90. ISSN 0268-3369, 1476-5365
Full text not available from this repository. (Request a copy)Abstract
Up to 40% of donor-recipient pairs in SCT have some degree of ABO incompatibility, which may cause severe complications. The aim of this study was to describe available options and survey current practices by means of a questionnaire circulated within the EBMT Pediatric Diseases Working Party investigators. Major ABO incompatibility (donor's RBCs have antigens missing on the recipient's cell surface, towards which the recipient has circulating isohemagglutinins) requires most frequently an intervention in case of bone marrow grafts, as immediate or delayed hemolysis, delayed erythropoiesis and pure red cell aplasia may occur. RBC depletion from the graft (82%), recipient plasma-exchange (14%) were the most common practices, according to the survey. Graft manipulation is rarely needed in mobilized peripheral blood grafts. In case of minor incompatible grafts (donor has isohemagglutinins directed against recipient RBC antigens), isohemagglutinin depletion from the graft by plasma reduction/centrifugation may be considered, but acute tolerability of minor incompatible grafts is rarely an issue. According to the survey, minor ABO incompatibility was either managed by means of plasma removal from the graft, especially when isohemagglutinin titer was above a certain threshold, or led to no intervention at all (41%). Advantages and disadvantages of each method are discussed.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PROGENITOR-CELL TRANSPLANTATION; BONE-MARROW; TRANSFUSION; REDUCTION; DEPLETION; PLASMA; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Pädiatrische Hämatologie, Onkologie und Stammzelltransplantation |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 17 Jan 2022 15:51 |
| Last Modified: | 17 Jan 2022 15:51 |
| URI: | https://pred.uni-regensburg.de/id/eprint/44344 |
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