von Welser, Sophie Freifrau and Grube, Matthias and Ortmann, Olaf (2015) Invasive mole in a perimenopausal woman: a case report and systematic review. ARCHIVES OF GYNECOLOGY AND OBSTETRICS, 292 (6). pp. 1193-1199. ISSN 0932-0067, 1432-0711
Full text not available from this repository. (Request a copy)Abstract
Objective Gestational trophoblastic disease (GTD) is a term used for a group of pregnancy-related tumors. We present a case of a perimenopausal woman with invasive mole. A systematic review was performed to identify reports on GTD in older women and to determine adequate treatment options. Case A 51-year-old perimenopausal woman was admitted to hospital with abdominal feeling of pressure and nausea. Diagnostic curettage revealed hydatidiform mole. She also presented symptomatic hyperthyroidism with hypertensive blood pressure and uneasiness. After treatment with beta blockers and carbimazole, the patient underwent abdominal hysterectomy and bilateral oophorosalpingectomy. Histopathological examination confirmed an invasive hydatidiform mole (IHM). Serum beta-hCG has decreased from initially 300,000-100 unit/L after 4 weeks. Data sources A systematic review was performed to identify all prior cases of GTD in women over 50. We searched in Medline, The Cochrane Library and Embase, to identify any articles published in the English language after 1970 and before Oct 31, 2013 pertaining to GTD in older woman (50 years or older). Tabulation, integration, and results Ten records were included in the systematic review, involving 203 cases of trophoblastic disease in older women. Although the diagnosis of GTD in older women is rare, it should be considered especially in patients with suspicious intrauterine findings in transvaginal ultrasound examinations. Different treatments were performed. In a limited number of reports, older women with GTD underwent initial hysterectomy. Benefits are avoidance of chemotherapy-induced toxicity and reduced risk of recurrence. Hysterectomy should be performed by an experienced surgeon. Conclusion It is concluded that GTD is very rare in peri- or postmenopausal women. Treatment has to be individualized, and hysterectomy can be considered as an appropriate option.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GESTATIONAL TROPHOBLASTIC DISEASE; COMPLETE HYDATIDIFORM MOLE; WOMEN AGED 50; MANAGEMENT; NEOPLASIA; HYSTERECTOMY; PREGNANCY; Gestational trophoblastic disease (GTD); Invasive mole; Perimenopausal; Hysterectomy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Frauenheilkunde) Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 26 Aug 2020 09:58 |
| Last Modified: | 26 Aug 2020 09:58 |
| URI: | https://pred.uni-regensburg.de/id/eprint/4436 |
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