Stripecke, Renata and Muenz, Christian and Schuringa, Jan Jacob and Bissig, Karl-Dimiter and Soper, Brian and Meeham, Terrence and Yao, Li-Chin and Di Santo, James P. and Brehm, Michael and Rodriguez, Estefania and Wege, Anja Kathrin and Bonnet, Dominique and Guionaud, Silvia and Howard, Kristina E. and Kitchen, Scott and Klein, Florian and Saeb-Parsy, Kourosh and Sam, Johannes and Sharma, Amar Deep and Trumpp, Andreas and Trusolino, Livio and Bult, Carol and Shultz, Leonard (2020) Innovations, challenges, and minimal information for standardization of humanized mice. EMBO MOLECULAR MEDICINE, 12 (7): e8662. ISSN 1757-4676, 1757-4684
Full text not available from this repository. (Request a copy)Abstract
Mice xenotransplanted with human cells and/or expressing human gene products (also known as "humanized mice") recapitulate the human evolutionary specialization and diversity of genotypic and phenotypic traits. These models can provide a relevantin vivocontext for understanding of human-specific physiology and pathologies. Humanized mice have advanced toward mainstream preclinical models and are now at the forefront of biomedical research. Here, we considered innovations and challenges regarding the reconstitution of human immunity and human tissues, modeling of human infections and cancer, and the use of humanized mice for testing drugs or regenerative therapy products. As the number of publications exploring different facets of humanized mouse models has steadily increased in past years, it is becoming evident that standardized reporting is needed in the field. Therefore, an international community-driven resource called "Minimal Information for Standardization of Humanized Mice" (MISHUM) has been created for the purpose of enhancing rigor and reproducibility of studies in the field. WithinMISHUM, we propose comprehensive guidelines for reporting critical information generated using humanized mice.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HEMATOPOIETIC STEM-CELLS; BREAST-CANCER CELLS; LIVER CHIMERIC MICE; MOUSE MODEL; HUMAN HEPATOCYTES; IMMUNE-SYSTEM; HEPATITIS-B; ANTIBODY THERAPY; VIRUS-INFECTION; XENOGRAFTS; humanized mice; infections; PDX; immuno-oncology; regenerative medicine |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Frauenheilkunde) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 13 Apr 2021 07:32 |
| Last Modified: | 13 Apr 2021 07:32 |
| URI: | https://pred.uni-regensburg.de/id/eprint/44360 |
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