Gonzalez-Alvarado, Maria Nazareth and Roetger, Caroline and Berger, Laura and London, Barry and Haase, Stefanie and Kuhbandner, Kristina and Lee, De-Hyung and Linker, Ralf A. (2020) Functional role of endogenous Kv1.4 in experimental demyelination. JOURNAL OF NEUROIMMUNOLOGY, 343: 577227. ISSN 0165-5728, 1872-8421
Full text not available from this repository. (Request a copy)Abstract
During neuroinflammation, the shaker type potassium channel Kv1.4 is re-expressed in oligodendrocytes (Ol), but not immune cells. Here, we analyze the role of endogenous Kv1.4 in two demyelinating animal models of multiple sclerosis. While Kv1.4 deficiency in primary murine Ol led to a decreased proliferation rate in vitro, it did not exert an effect on Ol proliferation or on the extent of de- or remyelination in the cuprizone model in vivo. However, in experimental autoimmune encephalomyelitis, Kv1.4(-/-) mice exhibited a milder disease course and reduced Th1 responses. These data argue for an indirect effect of Kv1.4 on immune cells, possibly via glial cells.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | POTASSIUM CHANNEL; MULTIPLE-SCLEROSIS; CNS; REMYELINATION; CELLS; PROGRESSION; EXPRESSION; CUPRIZONE; RESIDENT; DISEASE; Oligodendrocytes; Kv1.4; Remyelination; EAE; Cuprizone; Multiple sclerosis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Mar 2021 11:38 |
| Last Modified: | 22 Mar 2021 11:38 |
| URI: | https://pred.uni-regensburg.de/id/eprint/44387 |
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