Fisser, Christoph and Goetz, Kristina and Hetzenecker, Andrea and Debl, Kurt and Zeman, Florian and Hamer, Okka W. and Poschenrieder, Florian and Fellner, Claudia and Stadler, Stefan and Maier, Lars S. and Pfeifer, Michael and Buchner, Stefan and Arzt, Michael (2020) Obstructive sleep apnoea but not central sleep apnoea is associated with left ventricular remodelling after acute myocardial infarction. CLINICAL RESEARCH IN CARDIOLOGY. ISSN 1861-0684, 1861-0692
Full text not available from this repository. (Request a copy)Abstract
Obejctive Obstructive sleep apnoea (OSA) increases left ventricular transmural pressure more than central sleep apnoea (CSA) owing to negative intrathoracic pressure swings. We tested the hypothesis that the severity of OSA, and not CSA, is therefore associated with spheric cardiac remodelling after acute myocardial infarction. Methods This sub-analysis of a prospective observational study included 24 patients with acute myocardial infarction who underwent primary percutaneous coronary intervention. Spheric remodelling, calculated according to the sphericity index, was assessed by cardiac magnetic resonance imaging at baseline and 12 weeks after acute myocardial infarction. OSA and CSA [apnoea-hypopnoea index (AHI) >= 5/hour] were diagnosed by polysomnography. Results Within 12 weeks after acute myocardial infarction, patients with OSA exhibited a significant increase in systolic sphericity index compared to patients without sleep-disordered breathing (no SDB) and patients with CSA (OSA vs. CSA vs. no SDB: 0.05 +/- 0.04 vs. 0.01 +/- 0.04 vs. - 0.03 +/- 0.03,p = 0.002). In contrast to CSA, the severity of OSA was associated with an increase in systolic sphericity index after accounting for TIMI-flow before percutaneous coronary intervention, infarct size, pain-to-balloon-time and systolic blood pressure [OSA: B (95% CI) 0.443 (0.021; 0.816),p = 0.040; CSA: 0.193 (- 0.134; 0.300),p = 0.385]. Conclusion In contrast to CSA and no SDB, OSA is associated with spheric cardiac remodelling within the first 12 weeks after acute myocardial infarction. Data suggest that OSA-related negative intrathoracic pressure swings may contribute to this remodelling after acute myocardial infaction. [GRAPHICS] .
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | POSITIVE AIRWAY PRESSURE; CORONARY-ARTERY-DISEASE; ST-SEGMENT ELEVATION; HEART-FAILURE; SPHERICITY; CARDIOLOGY; GEOMETRY; RECOVERY; IMPACT; SHAPE; Myocardial infarction; Sleep apnoea; Sphericity; Cardiac remodelling; Wall thickness; Aneurysm; Cardiac magnetic resonance |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II Medicine > Lehrstuhl für Röntgendiagnostik Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien |
| Depositing User: | Petra Gürster |
| Date Deposited: | 14 Apr 2021 05:03 |
| Last Modified: | 14 Apr 2021 05:03 |
| URI: | https://pred.uni-regensburg.de/id/eprint/44407 |
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