Broman, Lars Mikael and Westlund, C. Jerker and Gilbers, Martijn and da Camara, Luisa Perry and Wittberg, Lisa Prahl and Taccone, Fabio Silvio and Malfertheiner, Maximilian and Di Nardo, Matteo and Swol, Justyna and Vercaemst, Leen and Barrett, Nicholas A. and Pappalardo, Federico and Belohlavek, Jan and Belliato, Mirko and Lorusso, Roberto (2020) Pressure and flow properties of dual-lumen cannulae for extracorporeal membrane oxygenation. PERFUSION-UK, 35 (8): 0267659120. pp. 736-744. ISSN 0267-6591, 1477-111X
Full text not available from this repository. (Request a copy)Abstract
Introduction: In the last decade, dual-lumen cannulae have been increasingly applied in patients undergoing extracorporeal life support. Well-performing vascular access is crucial for efficient extracorporeal membrane oxygenation support; thus, guidance for proper cannulae size is required. Pressure-flow charts provided by manufacturers are often based on tests performed using water, rarely blood. However, blood is a shear-thinning and viscoelastic fluid characterized by different flow properties than water. Methods: We performed a study evaluating pressure-flow curves during standardized conditions using human whole blood in two commonly available dual-lumen cannulae used in neonates, pediatric, and adult patients. Results were merged and compared with the manufacturer's corresponding curves obtained from the public domain. Results: The results showed that using blood as compared with water predominantly influenced drainage flow. A 10-80% higher pressure-drop was needed to obtain same drainage flow (hematocrit of 26%) compared with manufacturer's water charts in 13-31 Fr bi-caval dual-lumen cannulae. The same net difference was found in cavo-atrial cannulae (16-32 Fr), where a lower drainage pressure was required (Hct of 26%) compared with the manufacturer's test using blood with an Hct of 33%. Return pressure-flow data were similar, independent whether pumping blood or water, to the data reported by manufacturers. Conclusion: Non-standardized testing of pressure-flow properties of extracorporeal membrane oxygenation dual-lumen cannulae prevents an adequate prediction of pressure-flow results when these cannulae are used in patients. Properties of dual-lumen cannulae may vary between sizes within same cannula family, in particular concerning the drainage flow.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NON-NEWTONIAN PROPERTIES; BLOOD; ECMO; RECIRCULATION; PERFORMANCE; THROMBOSIS; AWAKE; extracorporeal membrane oxygenation; dual lumen; cannula; venous; pressure-flow; blood; water |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Mar 2021 08:29 |
| Last Modified: | 22 Mar 2021 08:29 |
| URI: | https://pred.uni-regensburg.de/id/eprint/44413 |
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