Mooren, Frank C. and Krueger, Karsten and Ringseis, Robert and Eder, Klaus and Liebisch, Gerhard and Conrad, Kerstin and Alack, Katharina and Maleki, Behzad Hajizadeh (2020) Combined effects of moderate exercise and short-term fasting on markers of immune function in healthy human subjects. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 318 (6). R1103-R1115. ISSN 0363-6119, 1522-1490
Full text not available from this repository. (Request a copy)Abstract
This study aimed to investigate the effects of a short-term (36 h) fasting period combined with an acute bout of exercise on markers of immune function and inflammation in healthy human subjects. Fourteen moderately trained male subjects (aged 19-39 yr) participated in a 36-h fasting trial (FA-T), followed by an acute bout of moderate exercise (60% (V) over dot (O2max)). After 1 wk. the same subjects, as their own control, participated in a non fasting trial (NFA-T) in which they performed an exercise trial of the same duration and intensity. Blood samples were taken before, immediately after, and 1 h after each exercise bout and analyzed for several immunological and metabolic markers. At baseline, fasting subjects showed lower levels of T cell apoptosis, lymphocyte-proliferative responses. IL-6, monocyte chemoattractant protein-1 (MCP-1), insulin, and leptin (P < 0.05) as well as higher levels of neutrophil oxidative burst and thiobarbituric acid reactive substances (TBARS) than those in the NFA-T (P < 0.05). After the exercise protocol, fasted subjects revealed higher T cell apoptosis. neutrophil oxidative burst. TBARS, TNF alpha, and MCP-1 levels as well as lower levels of lymphocyte-proliferative response, IL-6, insulin, and leptin than those in the NFA-T (P < 0.05). Short-term fasting aggravates perturbations in markers of immune function, and inflammation was induced by an acute moderate-intensity exercise protocol.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CALORIC RESTRICTION; L-CARNITINE; GAMMA-BUTYROBETAINE; FATTY-ACIDS; INTENSITY; APOPTOSIS; SYSTEM; CELLS; INFLAMMATION; COMBINATION; apoptosis; exercise; fasting; immune function; lymphocyte |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Mar 2021 08:30 |
| Last Modified: | 22 Mar 2021 08:30 |
| URI: | https://pred.uni-regensburg.de/id/eprint/44432 |
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