Enhanced Resorption of Liposomal Packed Vitamin C Monitored by Ultrasound

Prantl, Lukas and Eigenberger, Andreas and Gehmert, Sebastian and Haerteis, Silke and Thiha Aung, and Rachel, Reinhard and Jung, Ernst Michael and Felthaus, Oliver (2020) Enhanced Resorption of Liposomal Packed Vitamin C Monitored by Ultrasound. JOURNAL OF CLINICAL MEDICINE, 9 (6): 1616. ISSN , 2077-0383

Full text not available from this repository. (Request a copy)

Abstract

Vitamin C is an essential nutrient for humans and is involved in a plethora of health-related functions. Several studies have shown a connection between vitamin C intake and an improved resistance to infections that involves the immune system. However, the body cannot store vitamin C and both the elevated oral intake, and the intravenous application have certain disadvantages. In this study, we wanted to show a new formulation for the liposomal packaging of vitamin C. Using freeze etching electron microscopy, we show the formed liposomes. With a novel approach of post-processing procedures of real-time sonography that combines enhancement effects by contrast-like ultrasound with a transducer, we wanted to demonstrate the elevated intestinal vitamin C resorption on four participants. With the method presented in this study, it is possible to make use of the liposomal packaging of vitamin C with simple household materials and equipment for intake elevation. For the first time, we show the enhanced resorption of ingested liposomes using microbubble enhanced ultrasound imaging.

Item Type: Article
Uncontrolled Keywords: ASCORBIC-ACID; OXIDATIVE STRESS; CONTRAST AGENT; MITOCHONDRIAL DYSFUNCTION; PHOSPHATIDYLCHOLINE; DEFICIENCY; CULTURES; GULO; CEUS; vitamin C; immune system; liposomal packing; sonography; enhanced resorption
Subjects: 500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Divisions: Medicine > Lehrstuhl für Röntgendiagnostik
Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Plastische-, Hand- und Wiederherstellungschirurgie
Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Mikrobiologie (Archaeenzentrum)
Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Mikrobiologie (Archaeenzentrum) > Prof. Dr. Reinhard Rachel
Biology, Preclinical Medicine > Institut für Anatomie
Biology, Preclinical Medicine > Institut für Anatomie > Lehrstuhl für Molekulare und zelluläre Anatomie
Depositing User: Dr. Gernot Deinzer
Date Deposited: 22 Mar 2021 09:25
Last Modified: 22 Mar 2021 09:25
URI: https://pred.uni-regensburg.de/id/eprint/44445

Actions (login required)

View Item View Item