Bittner, Stefan and Steffen, Falk and Uphaus, Timo and Muthuraman, Muthuraman and Fleischer, Vinzenz and Salmen, Anke and Luessi, Felix and Berthele, Achim and Klotz, Luisa and Meuth, Sven G. and Bayas, Antonios and Paul, Friedemann and Hartung, Hans-Peter and Linker, Ralf and Heesen, Christoph and Stangel, Martin and Wildemann, Brigitte and Bergh, Florian Then and Tackenberg, Bjoern and Kuempfel, Tania and Weber, Frank and Zettl, Uwe K. and Ziemann, Ulf and Tumani, Hayrettin and Groppa, Sergiu and Muehlau, Mark and Lukas, Carsten and Hemmer, Bernhard and Wiendl, Heinz and Gold, Ralf and Zipp, Frauke (2020) Clinical implications of serum neurofilament in newly diagnosed MS patients: A longitudinal multicentre cohort study. EBIOMEDICINE, 56: 102807. ISSN 2352-3964,
Full text not available from this repository. (Request a copy)Abstract
Background: We aim to evaluate serum neurofilament light chain (sNfL), indicating neuroaxonal damage, as a biomarker at diagnosis in a large cohort of early multiple sclerosis (MS) patients. Methods: In a multicentre prospective longitudinal observational cohort, patients with newly diagnosed relapsing-remitting MS (RRMS) or clinically isolated syndrome (CIS) were recruited between August 2010 and November 2015 in 22 centers. Clinical parameters, MRI, and sNfL levels (measured by single molecule array) were assessed at baseline and up to four-year follow-up. Findings: Of 814 patients, 54.7% (445) were diagnosed with RRMS and 45.3% (369) with CIS when applying 2010 McDonald criteria (RRMS[2010] and CIS[2010]). After reclassification of CIS[2010] patients with existing CSF analysis, according to 2017 criteria, sNfL levels were lower in CIS[2017] than RRMS[2017] patients (9.1 pg/ml, IQR 6.2-13.7 pg/ml, n = 45; 10.8 pg/ml, IQR 7.4-20.1 pg/ml, n = 213; p = 0.036). sNfL levels correlated with number of T2 and Gd+ lesions at baseline and future clinical relapses. Patients receiving disease-modifying therapy (DMT) during the first four years had higher baseline sNfL levels than DMT-naive patients (11.8 pg/ml, IQR 7.5-20.7 pg/ml, n = 726; 9.7 pg/ml, IQR 6.4-15.3 pg/ml, n = 88). Therapy escalation decisions within this period were reflected by longitudinal changes in sNfL levels. Interpretation: Assessment of sNfL increases diagnostic accuracy, is associated with disease course prognosis and may, particularly when measured longitudinally, facilitate therapeutic decisions. (C) 2020 The Authors. Published by Elsevier B.V.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MULTIPLE-SCLEROSIS; MRI CRITERIA; CONVERSION; ATROPHY; LIGHT; Neurofilament light chain; sNfL; Multiple sclerosis; Prediction; Biomarker |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Mar 2021 09:28 |
| Last Modified: | 22 Mar 2021 09:28 |
| URI: | https://pred.uni-regensburg.de/id/eprint/44448 |
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