Ferreira, Manuel A. R. and Vonk, Judith M. and Baurecht, Hansjoerg and Marenholz, Ingo and Tian, Chao and Hoffman, Joshua D. and Helmer, Quinta and Tillander, Annika and Ullemar, Vilhelmina and Lu, Yi and Grosche, Sarah and Rueschendorf, Franz and Granell, Raquel and Brumpton, Ben M. and Fritsche, Lars G. and Bhatta, Laxmi and Gabrielsen, Maiken E. and Nielsen, Jonas B. and Zhou, Wei and Hveem, Kristian and Langhammer, Arnulf and Holmen, Oddgeir L. and Loset, Mari and Abecasis, Goncalo R. and Willer, Cristen J. and Emami, Nima C. and Cavazos, Taylor B. and Witte, John S. and Szwajda, Agnieszka and Hinds, David A. and Huebner, Norbert and Weidinger, Stephan and Magnusson, Patrik K. E. and Jorgenson, Eric and Karlsson, Robert and Paternoster, Lavinia and Boomsma, Dorret and Almqvist, Catarina and Lee, Young-Ae and Koppelman, Gerard H. (2020) Age-of-onset information helps identify 76 genetic variants associated with allergic disease. PLOS GENETICS, 16 (6): e1008725. ISSN 1553-7404,
Full text not available from this repository. (Request a copy)Abstract
Risk factors that contribute to inter-individual differences in the age-of-onset of allergic diseases are poorly understood. The aim of this study was to identify genetic risk variants associated with the age at which symptoms of allergic disease first develop, considering information from asthma, hay fever and eczema. Self-reported age-of-onset information was available for 117,130 genotyped individuals of European ancestry from the UK Biobank study. For each individual, we identified the earliest age at which asthma, hay fever and/or eczema was first diagnosed and performed a genome-wide association study (GWAS) of this combined age-of-onset phenotype. We identified 50 variants with a significant independent association (P<3x10(-8)) with age-of-onset. Forty-five variants had comparable effects on the onset of the three individual diseases and 38 were also associated with allergic disease case-control status in an independent study (n= 222,484). We observed a strong negative genetic correlation between age-of-onset and case-control status of allergic disease (r(g)= -0.63,P= 4.5x10(-61)), indicating that cases with early disease onset have a greater burden of allergy risk alleles than those with late disease onset. Subsequently, a multivariate GWAS of age-of-onset and case-control status identified a further 26 associations that were missed by the univariate analyses of age-of-onset or case-control status only. Collectively, of the 76 variants identified, 18 represent novel associations for allergic disease. We identified 81 likely target genes of the 76 associated variants based on information from expression quantitative trait loci (eQTL) and non-synonymous variants, of which we highlightADAM15,FOSL2,TRIM8,BMPR2,CD200R1,PRKCQ,NOD2,SMAD4,ABCA7andUBE2L3. Our results support the notion that early and late onset allergic disease have partly distinct genetic architectures, potentially explaining known differences in pathophysiology between individuals. Author summary So far, genetic studies of allergic disease have investigated the presence of the disease rather than the age at which the first allergic symptoms develop. We aimed to identify genetic risk variants associated with the age at which symptoms of allergic disease first develop, considering information from asthma, hay fever and eczema by examining 117,130 genotyped individuals of European ancestry from the UK Biobank study. We identified 50 variants with a significant independent association (P<3x10(-8)) with age-of-onset. Forty-five variants had comparable effects on the onset of the three individual diseases and 38 were also associated with allergic disease case-control status in an independent study (n= 222,484). We then performed a multivariate GWAS of age-of-onset and case-control status identified a further 26 associations that were missed by the univariate analyses of age-of-onset or case-control status only. 18 of 76 variants identified represent novel associations for allergic disease. We identified 81 likely target genes of the 76 genetic variants, includingADAM15,FOSL2,TRIM8,BMPR2,CD200R1,PRKCQ,NOD2,SMAD4,ABCA7andUBE2L3. Our results support the notion that early and late onset allergic disease have partly distinct genetic architectures, potentially explaining known differences in pathophysiology between individuals.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GENOME-WIDE ASSOCIATION; ATOPIC-DERMATITIS; SUSCEPTIBILITY LOCI; T-CELLS; CD200 RECEPTOR; II RECEPTOR; RISK LOCI; HAY-FEVER; PKC-THETA; ASTHMA; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Mar 2021 12:08 |
| Last Modified: | 22 Mar 2021 12:08 |
| URI: | https://pred.uni-regensburg.de/id/eprint/44454 |
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