Salaj, Martin and Druga, Rastislav and Cerman, Jiri and Kubova, Hana and Barinka, Filip (2015) Calretinin and parvalbumin immunoreactive interneurons in the retrosplenial cortex of the rat brain: Qualitative and quantitative analyses. BRAIN RESEARCH, 1627. pp. 201-215. ISSN 0006-8993, 1872-6240
Full text not available from this repository. (Request a copy)Abstract
The retrosplenial cortex (RSC) is a mesocortical region broadly involved with memory and navigation. It shares many characteristics with the perirhinal cortex (PRC), both of which appear to be significantly involved in the spreading of epileptic activity. We hypothesized that RSC possesses an interneuronal composition similar to that of PRC. To prove the hypothesis we studied the general pattern of calretinin (CR) and parvalbumin (PV) immunoreactivity in the RSC of the rat brain, its optical density as well as the morphological features and density of CR- and PV-immunoreactive (CR+ and PV+) interneurons. We also analyzed the overall neuronal density on Nissl-stained sections in RSC. Finally, we compared our results with our earlier analysis of PRC (Barinka et al., 2012). Compared to PRC, RSC was observed to have a higher intensity of PV staining and lower intensity of CR staining of neuropil. Vertically-oriented bipolar neurons were the most common morphological type among CR+ neurons. The staining pattern did not allow for a similarly detailed analysis of somatodendritic morphology of PV+ neurons. RSC possessed lower absolute (i.e., neurons/mm(3)) and relative (i.e., percentage of the overall neuronal population) densities of CR+ neurons and similar absolute and lower relative densities of PV+ neurons relative to PRC. CR: PV neuronal ratio in RSC (1:2 in area 29 and 1:2.2 in area 30) differed from PRC (1:1.2 in area 35 and 1:1.7 in area 36). In conclusion, RSC, although similar in many aspects to PRC, differs strikingly in the interneuronal composition relative to PRC. (C) 2015 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GENE-EXPRESSION PROFILES; LOCAL-CIRCUIT NEURONS; CORTICES IN-VITRO; GRANULAR-B-CORTEX; PERIRHINAL CORTEX; PREFRONTAL CORTEX; STATUS EPILEPTICUS; GABAERGIC NEURONS; KINDLED SEIZURES; NEOCORTEX; Retrosplenial cortex; Calretinin; Parvalbumin; Interneurons; Calcium-binding proteins; Perirhinal cortex |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 May 2019 08:28 |
| Last Modified: | 07 May 2019 08:28 |
| URI: | https://pred.uni-regensburg.de/id/eprint/4446 |
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