Sinner, Barbara (2020) Anaesthetic-induced neurotoxicity in children. Current state of science. ANASTHESIOLOGIE & INTENSIVMEDIZIN, 61 (6). pp. 204-214. ISSN 0170-5334, 1439-0256
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Human brain development is a complex process consisting of neuronal cell differentiation, migration and proliferation. Various factors contribute to brain development, e.g. the neurotransmitters glutamate and GABA, both are targets for anaesthetics. A number of experimental studies show that all clinically used anaesthetics are potentially toxic to the developing brain and induce apoptosis. Newborn rodents and primates exposed to anaesthetics exhibited a significantly inferior neurocognitive performance compared to animals not exposed to an anaesthetic drug. As a result of these animal experiments various retrospective studies were performed in humans. They revealed no unequivocal relationship between the exposure to anaesthesia at a young age and the development of learning disabilities or behavioural disorders. However, the exposure to two or more anaesthetic procedures was associated with cognitive deficits. Three prospective studies, PANDA, MASK and GAS, could not detect a neurocognitive difference between children who were exposed to anaesthesia and those who were not. In 2016, the FDA published a warning stating that repeated exposure to anaesthetics in the last trimester of pregnancy or given to newborns and infants might affect neurocognitive development.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NEURONS IN-VITRO; REQUIRING GENERAL-ANESTHESIA; AWAKE-REGIONAL ANESTHESIA; YOUNG-CHILDREN; BEHAVIORAL OUTCOMES; EARLY-CHILDHOOD; EARLY EXPOSURE; NEURODEVELOPMENTAL OUTCOMES; LEARNING-DISABILITIES; ISOFLURANE ANESTHESIA; Paediatrics; Anaesthesia, Neurodevelopment; Neurotoxicity |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 13 Apr 2021 06:47 |
| Last Modified: | 13 Apr 2021 06:47 |
| URI: | https://pred.uni-regensburg.de/id/eprint/44472 |
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