Mohr, Yorck and Hisler, Gaelle and Grousset, Leone and Roux, Yoann and Quadrelli, Elsje Alessandra and Wisser, Florian M. and Canivet, Jerome (2020) Nickel-catalyzed and Li-mediated regiospecific C-H arylation of benzothiophenes. GREEN CHEMISTRY, 22 (10). pp. 3155-3161. ISSN 1463-9262, 1463-9270
Full text not available from this repository. (Request a copy)Abstract
A nickel-based catalytic system for the regiospecific C2-H arylation of benzothiophene has been established. NiCl2(bpy) is used as a catalyst in combination with LiHMDS as a base in dioxane. The catalytic system is applicable to a variety of functionalized benzothiophenes, as well as other heteroarenes including thiophene, benzodithiophene, benzofuran and selenophene in combination with iodo aryl electrophiles. The role of LiHMDS as a uniquely potent base and a postulated mechanism are discussed. The applicability of this system is finally demonstrated for the synthesis of an intermediate of an active pharmaceutical ingredient.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EFFICIENT SYNTHESIS; FUNCTIONALIZATION; HETEROARENES; RALOXIFENE; ACCESS; PD; DERIVATIVES; THIOPHENE; COUPLINGS; INDOLES; |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Anorganische Chemie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Mar 2021 11:33 |
| Last Modified: | 23 Mar 2021 11:33 |
| URI: | https://pred.uni-regensburg.de/id/eprint/44536 |
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