Dourcy, Mickael and Maquee, Celine and Dams, Lorene and Gilliaux, Gautier and Javaux, Justine and Desmecht, Daniel and Mack, Matthias and Dewals, Benjamin G. and Machiels, Benedicte and Gillet, Laurent (2020) A gammaherpesvirus licenses CD8 T cells to protect the host from pneumovirus-induced immunopathologies. MUCOSAL IMMUNOLOGY, 13 (5). pp. 799-813. ISSN 1933-0219, 1935-3456
Full text not available from this repository. (Request a copy)Abstract
Human respiratory syncytial virus (RSV) is a pneumovirus that causes severe infections in infants worldwide. Despite intensive research, safe and effective vaccines against RSV have remained elusive. The main reason is that RSV infection of children previously immunized with formalin-inactivated-RSV vaccines has been associated with exacerbated pathology, a phenomenon called RSV vaccine-enhanced respiratory disease. In parallel, despite the high RSV prevalence, only a minor proportion of children develop severe diseases. Interestingly, variation in the immune responses against RSV or following RSV vaccination could be linked with differences of exposure to microbes during childhood. Gammaherpesviruses (gamma HVs), such as the Epstein-Barr virus, are persistent viruses that deeply influence the immune system of their host and could therefore affect the development of pneumovirus-induced immunopathologies for the long term. Here, we showed that a previous gamma HV infection protects against both pneumovirus vaccine-enhanced disease and pneumovirus primary infection and that CD8 T cells are essential for this protection. These observations shed a new light on the understanding of pneumovirus-induced diseases and open new perspectives for the development of vaccine strategies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RESPIRATORY SYNCYTIAL VIRUS; ALVEOLAR MACROPHAGES; IMMUNE-RESPONSES; PNEUMONIA VIRUS; INFLUENZA-VIRUS; INNATE-LIKE; INFECTION; EOSINOPHILS; DISEASE; HYGIENE; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Nephrologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Mar 2021 12:28 |
| Last Modified: | 23 Mar 2021 12:28 |
| URI: | https://pred.uni-regensburg.de/id/eprint/44550 |
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