Rein-Fischboeck, Lisa and Krautbauer, Sabrina and Eisinger, Kristina and Pohl, Rebekka and Meier, Elisabeth M. and Weiss, Thomas S. and Buechler, Christa (2015) Hepatic scavenger receptor BI is associated with type 2 diabetes but unrelated to human and murine non-alcoholic fatty liver disease. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 467 (2). pp. 377-382. ISSN 0006-291X, 1090-2104
Full text not available from this repository. (Request a copy)Abstract
Scavenger receptor, class B type I (SR-BI) is a physiologically relevant regulator of high density lipoprotein (HDL) metabolism. Low HDL is a common feature of patients with non-alcoholic fatty liver disease (NAFLD). Here, hepatic SR-BI expression was analyzed in human and murine NAFLD. In primary human hepatocytes NAFLD relevant factors like inflammatory cytokines, lipopolysaccharide and TGF-beta did not affect SR-BI protein. Similarly, oleate and palmitate had no effect. The adipokines chemerin, adiponectin, leptin and omentin did not regulate SR-BI expression. Accordingly, hepatic SR-BI was not changed in human and murine fatty liver and non-alcoholic steatohepatits. SR-BI was higher in type 2 diabetes patients but not in those with hypercholesterolemia. The current study indicates a minor if any role of SR-BI in human and murine NAFLD. (C) 2015 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DENSITY-LIPOPROTEIN RECEPTOR; SR-BI; METABOLIC SYNDROME; OBESE MICE; HDL; EXPRESSION; STEATOHEPATITIS; ATHEROSCLEROSIS; OVEREXPRESSION; ADIPOCYTOKINES; Adipokine; Liver steatosis; Fibrosis; Dyslipidemia |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 May 2019 12:21 |
| Last Modified: | 06 May 2019 12:21 |
| URI: | https://pred.uni-regensburg.de/id/eprint/4459 |
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