Kuehlmann, Britta and Bonham, Clark A. and Zucal, Isabel and Prantl, Lukas and Gurtner, Geoffrey C. (2020) Mechanotransduction in Wound Healing and Fibrosis. JOURNAL OF CLINICAL MEDICINE, 9 (5): 1423. ISSN 2077-0383
Full text not available from this repository. (Request a copy)Abstract
Skin injury is a common occurrence and mechanical forces are known to significantly impact the biological processes of skin regeneration and wound healing. Immediately following the disruption of the skin, the process of wound healing begins, bringing together numerous cell types to collaborate in several sequential phases. These cells produce a multitude of molecules and initiate multiple signaling pathways that are associated with skin disorders and abnormal wound healing, including hypertrophic scars, keloids, and chronic wounds. Studies have shown that mechanical forces can alter the microenvironment of a healing wound, causing changes in cellular function, motility, and signaling. A better understanding of the mechanobiology of cells in the skin is essential in the development of efficacious therapeutics to reduce skin disorders, normalize abnormal wound healing, and minimize scar formation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FOCAL ADHESION KINASE; HYPERTROPHIC SCAR FORMATION; BETA-CATENIN STABILIZATION; CALCIUM-CHANNEL BLOCKER; TGF-BETA; CELL-PROLIFERATION; PULMONARY-FIBROSIS; SURGICAL INCISIONS; LATENT TGF-BETA-1; REVISION SURGERY; mechanotransduction; fibrosis; wound healing |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Plastische-, Hand- und Wiederherstellungschirurgie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 13 Apr 2021 05:30 |
| Last Modified: | 13 Apr 2021 05:30 |
| URI: | https://pred.uni-regensburg.de/id/eprint/44630 |
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