Siska, Peter J. and Singer, Katrin and Evert, Katja and Renner, Kathrin and Kreutz, Marina (2020) The immunological Warburg effect: Can a metabolic-tumor-stroma score (MeTS) guide cancer immunotherapy? IMMUNOLOGICAL REVIEWS, 295 (1). pp. 187-202. ISSN 0105-2896, 1600-065X
Full text not available from this repository. (Request a copy)Abstract
The "glycolytic switch" also known as the "Warburg effect" is a key feature of tumor cells and leads to the accumulation of lactate and protons in the tumor environment. Intriguingly, non-malignant lymphocytes or stromal cells such as tumor-associated macrophages and cancer-associated fibroblasts contribute to the lactate accumulation in the tumor environment, a phenomenon described as the "Reverse Warburg effect." Localized lactic acidosis has a strong immunosuppressive effect and mediates an immune escape of tumors. However, some tumors do not display the Warburg phenotype and either rely on respiration or appear as a mosaic of cells with different metabolic properties. Based on these findings and on the knowledge that T cell infiltration is predictive for patient outcome, we suggest a metabolic-tumor-stroma score to determine the likelihood of a successful anti-tumor immune response: (a) a respiring tumor with high T cell infiltration ("hot"); (b) a reverse Warburg type with respiring tumor cells but glycolytic stromal cells; (c) a mixed type with glycolytic and respiring compartments; and (d) a glycolytic (Warburg) tumor with low T cell infiltration ("cold"). Here, we provide evidence that these types can be independent of the organ of origin, prognostically relevant and might help select the appropriate immunotherapy approach.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CD8(+) T-CELLS; HYPOXIA-INDUCIBLE FACTORS; SECRETED LACTIC-ACID; GLUCOSE-METABOLISM; SYNOVIAL-FLUID; LACTATE-DEHYDROGENASE; AEROBIC GLYCOLYSIS; DENDRITIC CELLS; IFN-GAMMA; C-MYC; acidification; GLUT; immunotherapies; lactate; T cell; Warburg |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Lehrstuhl für Pathologie Medicine > Zentren des Universitätsklinikums Regensburg > Regensburger Centrum für Interventionelle Immunologie (RCI) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 13 Apr 2021 05:08 |
| Last Modified: | 13 Apr 2021 05:08 |
| URI: | https://pred.uni-regensburg.de/id/eprint/44668 |
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