Iglesias-Escudero, Maria and Sansegundo-Arribas, David and Riquelme, Paloma and Merino-Fernandez, David and Guiral-Foz, Sandra and Perez, Carmen and Valero, Rosalia and Ruiz, Juan Carlos and Rodrigo, Emilio and Lamadrid-Perojo, Patricia and Hutchinson, James A. and Ochando, Jordi and Lopez-Hoyos, Marcos (2020) Myeloid-Derived Suppressor Cells in Kidney Transplant Recipients and the Effect of Maintenance Immunotherapy. FRONTIERS IN IMMUNOLOGY, 11: 643. ISSN 1664-3224,
Full text not available from this repository. (Request a copy)Abstract
Myeloid-derived suppressor cells (MDSC) represent a heterogeneous group of myeloid regulatory cells that were originally described in cancer. Several studies in animal models point to MDSC as important players in the induction of allograft tolerance due to their immune modulatory function. Most of the published studies have been performed in animal models, and the data addressing MDSCs in human organ transplantation are scarce. We evaluated the phenotype and function of different MDSCs subsets in 38 kidney transplant recipients (KTRs) at different time points. Our data indicate that monocytic MDSCs (Mo-MDSC) increase in KTR at 6 and 12 months posttransplantation. On the contrary, the percentages of polymorphonuclear MDSC (PMN-MDSC) and early-stage MDSC (e-MDSC) are not significantly increased. We evaluated the immunosuppressive activity of Mo-MDSC in KTR and confirmed their ability to increase regulatory T cells (Treg) in vitro. Interestingly, when we compared the ability of Mo-MDSC to suppress T cell proliferation, we observed that tacrolimus, but not rapamycin-treated KTR, was able to inhibit CD4(+) T cell proliferation in vitro. This indicates that, although mTOR inhibitors are widely regarded as supportive of regulatory responses, rapamycin may impair Mo-MDSC function, and suggests that the choice of immunosuppressive therapy may determine the tolerogenic pathway and participating immune cells that promote organ transplant acceptance in KTR.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RENAL-TRANSPLANT; MEDIATE; kidney transplantation; mTOR inhibition; myeloid-derived suppressor cells; tacrolimus; immunosuppression |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Mar 2021 05:28 |
| Last Modified: | 26 Mar 2021 05:28 |
| URI: | https://pred.uni-regensburg.de/id/eprint/44685 |
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