Azizov, Vugar and Dietel, Katharina and Steffen, Franziska and Duerholz, Kerstin and Meidenbauer, Julia and Lucas, Sebastien and Frech, Michael and Omata, Yasunori and Tajik, Narges and Knipfer, Lisa and Kolenbrander, Anne and Seubert, Silvia and Lapuente, Dennis and Sokolova, Maria V. and Hofmann, Joerg and Tenbusch, Matthias and Ramming, Andreas and Steffen, Ulrike and Nimmerjahn, Falk and Linker, Ralf and Wirtz, Stefan and Herrmann, Martin and Temchura, Vladimir and Sarter, Kerstin and Schett, Georg and Zaiss, Mario M. (2020) Ethanol consumption inhibits T-FH cell responses and the development of autoimmune arthritis. NATURE COMMUNICATIONS, 11 (1): 1998. ISSN 2041-1723,
Full text not available from this repository. (Request a copy)Abstract
Alcohol consumption is a consistent protective factor for the development of autoimmune diseases such as rheumatoid arthritis (RA). The underlying mechanism for this tolerance-inducing effect of alcohol, however, is unknown. Here we show that alcohol and its metabolite acetate alter the functional state of T follicular helper (T-FH) cells in vitro and in vivo, thereby exerting immune regulatory and tolerance-inducing properties. Alcohol-exposed mice have reduced Bcl6 and PD-1 expression as well as IL-21 production by T-FH cells, preventing proper spatial organization of T-FH cells to form T-FH:B cell conjugates in germinal centers. This effect is associated with impaired autoantibody formation, and mitigates experimental autoimmune arthritis. By contrast, T cell independent immune responses and passive models of arthritis are not affected by alcohol exposure. These data clarify the immune regulatory and tolerance-inducing effect of alcohol consumption. Moderate consumption of alcohol is associated with protection from some autoimmune diseases. Here the authors show that ethanol and its metabolite acetate can protect mice from collagen-induced arthritis and provide evidence that the mechanism of this effect might be via inhibition of the effector function of T follicular helper cells.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DEVELOPING RHEUMATOID-ARTHRITIS; ALCOHOL-CONSUMPTION; B-CELLS; HELPER-CELLS; BONE LOSS; DIFFERENTIATION; IL-21; RISK; EXPRESSION; BCL6; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Mar 2021 08:31 |
| Last Modified: | 26 Mar 2021 08:31 |
| URI: | https://pred.uni-regensburg.de/id/eprint/44704 |
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