Heitmann, Henrik and Haller, Bernhard and Tiemann, Laura and Muehlau, Mark and Berthele, Achim and Toelle, Thomas R. and Salmen, Anke and Ambrosius, Bjoern and Bayas, Antonios and Asseyer, Susanna and Hartung, Hans-Peter and Heesen, Christoph and Stangel, Martin and Wildemann, Brigitte and Haars, Sarah and Groppa, Sergiu and Luessi, Felix and Kuempfel, Tania and Nischwitz, Sandra and Meuth, Sven G. and Klotz, Luisa and Linker, Ralf A. and Zettl, Uwe K. and Ziemann, Ulf and Tumani, Hayrettin and Tackenberg, Bjoern and Zipp, Frauke and Wiendl, Heinz and Gold, Ralf and Hemmer, Bernhard and Ploner, Markus (2020) Longitudinal prevalence and determinants of pain in multiple sclerosis: results from the German National Multiple Sclerosis Cohort study. PAIN, 161 (4). pp. 787-796. ISSN 0304-3959, 1872-6623
Full text not available from this repository. (Request a copy)Abstract
Pain is frequent in multiple sclerosis (MS) and includes different types, with neuropathic pain (NP) being most closely related to MS pathology. However, prevalence estimates vary largely, and causal relationships between pain and biopsychosocial factors in MS are largely unknown. Longitudinal studies might help to clarify the prevalence and determinants of pain in MS. To this end, we analyzed data from 410 patients with newly diagnosed clinically isolated syndrome or relapsing-remitting MS participating in the prospective multicenter German National MS Cohort Study (NationMS) at baseline and after 4 years. Pain was assessed by self-report using the PainDETECT Questionnaire. Neuropsychiatric assessment included tests for fatigue, depression, and cognition. In addition, sociodemographic and clinical data were obtained. Prevalence of pain of any type was 40% and 36% at baseline and after 4 years, respectively, whereas prevalence of NP was 2% and 5%. Pain of any type and NP were both strongly linked to fatigue, depression, and disability. This link was even stronger after 4 years than at baseline. Moreover, changes in pain, depression, and fatigue were highly correlated without any of these symptoms preceding the others. Taken together, pain of any type seems to be much more frequent than NP in early nonprogressive MS. Moreover, the close relationship between pain, fatigue, and depression in MS should be considered for treatment decisions and future research on a possible common pathophysiology.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | QUALITY-OF-LIFE; NEUROPATHIC PAIN; MISSING DATA; FOLLOW-UP; FATIGUE; DEPRESSION; IMPAIRMENT; SCALE; Multiple sclerosis; Neuropathic pain; Epidemiology; Depression; Fatigue |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 Mar 2021 06:40 |
| Last Modified: | 29 Mar 2021 06:40 |
| URI: | https://pred.uni-regensburg.de/id/eprint/44846 |
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