Balavarca, Y. and Pearce, K. and Norden, J. and Collin, M. and Jackson, G. and Holler, E. and Dressel, R. and Kolb, H-J and Greinix, H. and Socie, G. and Toubert, A. and Rocha, V. and Gluckman, E. and Hromadnikova, I. and Sedlacek, P. and Wolff, D. and Holtick, U. and Dickinson, A. and Bickeboeller, H. (2015) Predicting survival using clinical risk scores and non-HLA immunogenetics. BONE MARROW TRANSPLANTATION, 50 (11). pp. 1445-1452. ISSN 0268-3369, 1476-5365
Full text not available from this repository. (Request a copy)Abstract
Previous studies of non-histocompatibility leukocyte antigen (HLA) gene single-nucleotide polymorphisms (SNPs) on subgroups of patients undergoing allogeneic haematopoietic stem cell transplantation (HSCT) revealed an association with transplant outcome. This study further evaluated the association of non-HLA polymorphisms with overall survival in a cohort of 762 HSCT patients using data on 26 polymorphisms in 16 non-HLA genes. When viewed in addition to an already established clinical risk score (EBMT-score), three polymorphisms: rs8177374 in the gene for MyD88-adapter-like (MAL; P = 0.026), rs9340799 in the oestrogen receptor gene (ESR; P = 0.003) and rs1800795 in interleukin-6 (IL-6; P = 0.007) were found to be associated with reduced overall survival, whereas the haplo-genotype (ACC/ACC) in IL-10 was protective (P = 0.02). The addition of these non-HLA polymorphisms in a Cox regression model alongside the EBMT-score improved discrimination between risk groups and increased the level of prediction compared with the EBMT-score alone (gain in prediction capability for EBMT-genetic-score 10.8%). Results also demonstrated how changes in clinical practice through time have altered the effects of non-HLA analysis. The study illustrates the significance of non-HLA genotyping prior to HSCT and the importance of further investigation into non-HLA gene polymorphisms in risk prediction.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | STEM-CELL TRANSPLANTATION; VERSUS-HOST-DISEASE; BONE-MARROW-TRANSPLANTATION; CHRONIC MYELOID-LEUKEMIA; GENE POLYMORPHISMS; PROMOTER POLYMORPHISM; IN-VITRO; MESSENGER-RNA; RECEPTOR; ASSOCIATION; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 May 2019 08:23 |
| Last Modified: | 06 May 2019 08:23 |
| URI: | https://pred.uni-regensburg.de/id/eprint/4487 |
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