Macabeo, Allan Patrick G. and Flores, Angeli Izza G. and Fernandez, Rey Arturo T. and Budde, Simon and Faderl, Christian and Dahse, Hans-Martin and Franzblau, Scott G. (2020) Antitubercular and cytotoxic polyoxygenated cyclohexane derivatives from Uvaria grandiflora. NATURAL PRODUCT RESEARCH. ISSN 1478-6419, 1478-6427
Full text not available from this repository. (Request a copy)Abstract
Chromatographic purification of the DCM sub-extract of Uvaria grandiflora led to the isolation and characterization of a new polyoxygenated cyclohexane derivative, grandifloranol (1), together with five known compounds. Among the compounds isolated, zeylenone (3) showed moderate antitubercular activity against Mycobacterium tuberculosis H(37)Rv with MIC90 value of 51.2 mu M and antiproliferative or cytotoxic activity against human myeloid leukaemia (K-562) and HeLa cells with IC50 values of 2.3 and 18.3 mu M, respectively.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CONSTITUENTS; Uvaria grandiflora; polyoxygenated cyclohexanes; antitubercular; cytotoxic |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 08 Apr 2021 05:40 |
| Last Modified: | 08 Apr 2021 05:40 |
| URI: | https://pred.uni-regensburg.de/id/eprint/44911 |
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