Duscha, Alexander and Gisevius, Barbara and Hirschberg, Sarah and Yissachar, Nissan and Stangl, Gabriele and Eilers, Eva and Bader, Verian and Haase, Stefanie and Kaisler, Johannes and David, Christina and Schneider, Ruth and Troisi, Riccardo and Zent, Daniel and Hegelmaier, Tobias and Dokalis, Nikolaos and Gerstein, Sara and Del Mare-Roumani, Sara and Amidror, Sivan and Staszewski, Ori and Poschmann, Gereon and Stuehler, Kai and Hirche, Frank and Balogh, Andras and Kempa, Stefan and Traeger, Pascal and Zaiss, Mario M. and Holm, Jacob Bak and Massa, Megan G. and Nielsen, Henrik Bjorn and Faissner, Andreas and Lukas, Carsten and Gatermann, Soeren G. and Scholz, Markus and Przuntek, Horst and Prinz, Marco and Forslund, Sofia K. and Winklhofer, Konstanze F. and Mueller, Dominik N. and Linker, Ralf A. and Gold, Ralf and Haghikia, Aiden (2020) Propionic Acid Shapes the Multiple Sclerosis Disease Course by an Immunomodulatory Mechanism. CELL, 180 (6). 1067-+. ISSN 0092-8674, 1097-4172
Full text not available from this repository. (Request a copy)Abstract
Short-chain fatty acids are processed from indigestible dietary fibers by gut bacteria and have immunomodulatory properties. Here, we investigate propionic acid (PA) in multiple sclerosis (MS), an autoimmune and neurodegenerative disease. Serum and feces of subjects with MS exhibited significantly reduced PA amounts compared with controls, particularly after the first relapse. In a proof-of-concept study, we supplemented PA to therapy-naive MS patients and as an add-on to MS immunotherapy. After 2 weeks of PA intake, we observed a significant and sustained increase of functionally competent regulatory T (Treg) cells, whereas Th1 and Th17 cells decreased significantly. Post-hoc analyses revealed a reduced annual relapse rate, disability stabilization, and reduced brain atrophy after 3 years of PA intake. Functional microbiome analysis revealed increased expression of Treg-cell-inducing genes in the intestine after PA intake. Furthermore, PA normalized Treg cell mitochondria! function and morphology in MS. Our findings suggest that PA can serve as a potent immunomodulatory supplement to MS drugs.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CHAIN FATTY-ACIDS; DIFFERENTIAL EXPRESSION ANALYSIS; AUTOIMMUNE ENCEPHALOMYELITIS; NERVOUS-SYSTEM; GUT MICROBIOTA; BUTYRATE; BACTERIA; METABOLITES; SEQUENCES; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 Mar 2021 10:09 |
| Last Modified: | 29 Mar 2021 10:09 |
| URI: | https://pred.uni-regensburg.de/id/eprint/44913 |
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