Reich, Anna and Wilke, Annika and Gediga, Guenther and Baurecht, Hansjoerg and Rodriguez, Elke and Jakasa, Ivone and Geier, Johannes and Mempel, Martin and Buhl, Timo and Weidinger, Stephan and Kezic, Sanja and John, Swen M. and Schoen, Michael P. and Brans, Richard (2020) Health education decreases incidence of hand eczema in metal work apprentices: Results of a controlled intervention study. CONTACT DERMATITIS, 82 (6). pp. 350-360. ISSN 0105-1873, 1600-0536
Full text not available from this repository. (Request a copy)Abstract
Background Metal work apprentices (MWAs) frequently develop work-related hand eczema (HE). Objectives To evaluate the effect of health education on incidence of work-related HE in MWAs and to assess confounding factors. Materials/methods In a prospective controlled intervention study, 131 MWAs received educational training on prevention of HE, whereas 172 MWAs and 118 office work apprentices served as controls. At baseline and during three yearly follow-ups, questionnaires were completed and hands were examined. Saliva samples were collected for assessment of filaggrin (FLG) null mutations and an explorative genome-wide association study (GWAS), and levels of various cytokines were assessed from stratum corneum samples. Results The 2-year and 3-year incidence of HE in the metalwork control group was 20.9% and 32.6%, respectively, which was significantly higher than in the intervention group (odds ratio [OR] 2.63, 95% confidence interval [CI] 1.31 to 5.28, P < .01 and OR 3.47, 95% CI 1.88 to 6.40, P < .0001). The knowledge score was higher in unaffected MWAs (P < .05). Other factors significantly associated with developing HE in MWAs were smoking cigarettes (P < .01) and FLG mutations (P < .001). No significant links were found regarding epidermal cytokine levels and GWAS. Conclusions Health education is effective in primary prevention of HE in MWAs. Individual factors should be considered in targeted counseling.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | OF-FUNCTION MUTATIONS; NATURAL MOISTURIZING FACTOR; FOLLOW-UP; CONTACT-DERMATITIS; ATOPIC-DERMATITIS; TOBACCO SMOKING; SKIN DISEASES; STRATUM-CORNEUM; SEVERITY INDEX; FILAGGRIN GENE; apprentices; hand eczema; health education; intervention; metal work; occupation; prevention; RRID; SCR_001905; work-related skin diseases |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 Mar 2021 10:08 |
| Last Modified: | 29 Mar 2021 10:08 |
| URI: | https://pred.uni-regensburg.de/id/eprint/44916 |
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