Chittka, Dominik and Lennartz, L. and Jung, B. and Banas, B. and Bergler, T. (2020) Successful rituximab treatment of recurrent glomerulonephritis associated with antibodies against the glomerular basement membrane. INTERNIST, 61 (4). pp. 416-423. ISSN 0020-9554, 1432-1289
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This article presents a case of recurrent anti-GBM disease (with antibodies against the glomerular basement membrane [GBM]) in a 17-year-old patient successfully treated with rituximab. Kidney biopsy with detection of linear deposition of immunoglobulin G (IgG) along the basement membrane is the diagnostic gold standard, which should be accompanied by serological testing. However, standard assays for the detection of anti-GBM antibodies have a high rate of false-negative results. In this particular case, an increase in proteinuria despite standard therapy (plasmapheresis, steroids, cyclophosphamide) was the clinical correlate of relapsing disease. The use of rituximab completely resolved the recurrent anti-GBM disease.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DISEASE; Anti-GBM disease; relapse; Acute kidney injury; Kidney biopsy; Antibodies; monoclonal; Plasma exchange |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 Mar 2021 08:17 |
| Last Modified: | 29 Mar 2021 08:17 |
| URI: | https://pred.uni-regensburg.de/id/eprint/44928 |
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