Gimenez, Maria Rubini and Miller, P. Elliott and Alviar, Carlos L. and van Diepen, Sean and Granger, Christopher B. and Montalescot, Gilles and Windecker, Stephan and Maier, Lars and Serpytis, Pranas and Serpytis, Rokas and Oldroyd, Keith G. and Noc, Marko and Fuernau, Georg and Huber, Kurt and Sandri, Marcus and de Waha-Thiele, Suzanne and Schneider, Steffen and Ouarrak, Taoufik and Zeymer, Uwe and Desch, Steffen and Thiele, Holger (2020) Outcomes Associated with Respiratory Failure for Patients with Cardiogenic Shock and Acute Myocardial Infarction: A Substudy of the CULPRIT-SHOCK Trial. JOURNAL OF CLINICAL MEDICINE, 9 (3): 860. ISSN , 2077-0383
Full text not available from this repository. (Request a copy)Abstract
Background: Little is known about clinical outcomes of patients with acute myocardial infraction (AMI) complicated by cardiogenic shock (CS) requiring mechanical ventilation (MV). The aim of this study was to identify the characteristics, risk factors, and outcomes associated with the provision of MV in this specific high-risk population. Methods: Patients with CS complicating AMI and multivessel coronary artery disease from the CULPRIT-SHOCK trial were included. We explored 30 days of clinical outcomes in patients not requiring MV, those with MV on admission, and those in whom MV was initiated within the first day after admission. Results: Among 683 randomized patients included in the analysis, 17.4% received no MV, 59.7% were ventilated at admission and 22.8% received MV within or after the first day after admission. Patients requiring MV had a different risk-profile. Factors independently associated with the provision of MV on admission included higher body weight, resuscitation within 24 h before admission, elevated heart rate and evidence of triple vessel disease. Conclusions: Requiring MV in patients with CS complicating AMI is common and independently associated with mortality after adjusting for covariates. Patients with delayed MV initiation appear to be at higher risk of adverse outcomes. Further research is necessary to identify the optimal timing of MV in this high-risk population.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | POSITIVE-PRESSURE VENTILATION; MECHANICAL VENTILATION; REVASCULARIZATION; SUPPORT; PEEP; cardiogenic shock; respiratory failure; mechanical ventilation; non-invasive ventilation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 Mar 2021 12:41 |
| Last Modified: | 29 Mar 2021 12:41 |
| URI: | https://pred.uni-regensburg.de/id/eprint/44994 |
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