Kuzin, Maxim and Schoretsanitis, Georgios and Haen, Ekkehard and Dammann, Gerhard and Hiemke, Christoph and Gruender, Gerhard and Paulzen, Michael (2020) The Effects of Co-prescription of Pantoprazole on the Clozapine Metabolism. PHARMACOPSYCHIATRY, 53 (2). pp. 65-70. ISSN 0176-3679, 1439-0795
Full text not available from this repository. (Request a copy)Abstract
Background Polypharmacy including somatic medications such as proton pump inhibitors is a common phenomenon in psychiatric care. The aim of this study was to evaluate the pantoprazole effects on clozapine metabolism. Methods A large therapeutic drug-monitoring database containing plasma concentrations of CLZ was analyzed. The results were stratified into four groups: a non-smoking (n = 250) and a smoking group (n = 326), and two groups co-medicated with pantoprazole: non-smokers ( n = 26) and smokers (n = 29). The analysis was based on the non-parametrical Mann-Whitney U test (M-W-U) with a significance level of 0.05. Results Differences reached statistical significance for pharmacokinetic parameters between CLZ monotherapy and comedication with pantoprazole neither in smokers nor in nonsmokers (p > 0.05 for M-W-U in pairwise comparisons). In patients with clozapine monotherapy, smokers had a higher daily dosage of CLZ compared to non-smokers (mean dosage 363 +/- 181 vs. 291 +/- 145 mg/day, p < 0.001 for M-W-U). Conclusions Adding pantoprazole to an ongoing treatment with clozapine does not alter the metabolism of clozapine to a significant extent.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PROTON PUMP INHIBITORS; PLASMA-CONCENTRATIONS; GENETIC-POLYMORPHISM; OMEPRAZOLE; SMOKING; CYTOCHROME-P450; SCHIZOPHRENIA; PERFORMANCE; RISPERIDONE; SERUM; therapeutic drug monitoring; clozapine; pantoprazole; CYP2C19; smokers |
| Subjects: | 600 Technology > 610 Medical sciences Medicine 600 Technology > 615 Pharmacy |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Mar 2021 05:42 |
| Last Modified: | 30 Mar 2021 05:42 |
| URI: | https://pred.uni-regensburg.de/id/eprint/45026 |
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