McLornan, Donal P. and Malpassuti, Vittoria and Lippinkhof-Kozijn, Anne and Potter, Victoria and Beelen, Dietrich and Bunjes, Donald and Sengeloev, Henrik and Radujkovic, Aleksandar and Passweg, Jakob and Chalandon, Yves and Kroeger, Nicolaus and Wulf, Gerald G. and Johansson, Jan-Erik and Ciceri, Fabio and Bornhaeuser, Martin and Holler, Ernst and Guffroy, Blandine and Martin, Sonja and Neubauer, Andreas and Gramatski, Martin and Robin, Marie and Iacobelli, Simona and Hayden, Patrick and Hernandez Boluda, Juan C. and Czerw, Tomasz and Yakoub-Agha, Ibrahim (2020) Outcome of allogeneic haematopoietic stem cell transplantation in myeloproliferative neoplasm, unclassifiable: a retrospective study by the Chronic Malignancies Working Party of the EBMT. BRITISH JOURNAL OF HAEMATOLOGY, 190 (3). pp. 437-441. ISSN 0007-1048, 1365-2141
Full text not available from this repository. (Request a copy)Abstract
Myeloproliferative Neoplasm (MPN), unclassifiable (MPN-U) is a heterogeneous disease with regards to both clinical phenotype and disease course. Patients may initially be asymptomatic or present with leucocytosis or thrombocytosis, anaemia, progressive splenomegaly, constitutional symptom, thromboses or accelerated/blastic phase disease. Treatment strategies are variable and there are no widely accepted consensus management guidelines for MNU-U. Allogeneic Haematopoietic Cell Transplantation (allo-HCT) remains the only curative strategy yet outcomes, to date, are not well defined. We hereby report on the largest retrospective study of patients with MPN-U undergoing allo-HCT, highlighting the potentially curative role and providing clinicians with robust engraftment, GvHD and outcome data to facilitate patient discussion.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SURVIVAL; allogeneic stem cell transplant; conditioning; myeloproliferative neoplasms unclassifiable; non-relapse mortality |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Mar 2021 09:13 |
| Last Modified: | 30 Mar 2021 09:13 |
| URI: | https://pred.uni-regensburg.de/id/eprint/45066 |
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