Karrasch, Stefan and Peters, Annette and Meisinger, Christa and Ferland, Maike and Jaeschke, Lina and Pischon, Tobias and Fricke, Julia and Keil, Thomas and Gastell, Sylvia and Schulze, Matthias and Brandes, Mirko and Guenther, Kathrin and Kuss, Oliver and Schikowski, Tamara and Emmel, Carina and Joeckel, Karl-Heinz and Michels, Karin B. and Franzke, Claus-Werner and Langer, Susan and Mikolajczyk, Rafael and Jagodzinski, Annika and Becher, Heiko and Castell, Stefanie and Kemmling, Yvonne and Waniek, Sabina and Lieb, Wolfgang and Wirkner, Kerstin and Loeffler, Markus and Greiser, Karin Halina and Kaaks, Rudolf and Legath, Nicole and Berger, Klaus and Schipf, Sabine and Hoffmann, Wolfgang and Sedlmeier, Anja and Leitzmann, Michael and Brenner, Hermann and Holleczek, Bernd and Schulz, Holger (2020) Lung function in the German National Cohort: methods and initial results. BUNDESGESUNDHEITSBLATT-GESUNDHEITSFORSCHUNG-GESUNDHEITSSCHUTZ, 63 (3). pp. 322-331. ISSN 1436-9990, 1437-1588
Full text not available from this repository. (Request a copy)Abstract
Background A nationwide assessment of the respiratory status on the basis of standardized lung function measurements has so far not been available in Germany. The present work describes the lung function tests in the German National Cohort (GNC) and presents initial results based on the GNC Midterm Baseline Dataset. Material and Methods The assessment of lung function in the GNC comprised spirometry (level 1) and the determination of exhaled nitric oxide (FeNO, level 2). Our quality assurance concept included regular training of lung function test procedures at various GNC sites, interim evaluations of test quality, as well as regular calibration/measurement checks of test equipment. For spirometry, we established a stepwise procedure for offline quality control based on raw flow volume curves. Results In the present dataset (n& x202f;= 101,734), spirometry was available for 86,893 study participants and FeNO was available for 15,228 participants. The average (+/- SD) FEV1 Z score (according to GLI 2012) was -0.321& x202f;+/- 1.047, the FVC Z score was -0.153& x202f;+/- 0.941, and the FEV1/FVC Z score was -0.337& x202f;+/- 0.901. The difference in FEV1/FVC between current smokers and never-smokers increased with age. The average FeNO was 14.2& x202f;divided by 2.0& x202f;ppb. Current smoking reduced FeNO levels by 43%, whereas respiratory allergy increased FeNO levels by 16% in nonsmokers. Discussion The results of spirometry and the FeNO measurements are in the expected range with regard to their distributions and correlates. The GNC provides a valuable basis for future investigations of respiratory health and its determinants as well as research into the prevention of respiratory diseases in Germany.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EXHALED NITRIC-OXIDE; SPIROMETRY; HEALTH; POPULATION; QUALITY; COPD; STANDARDIZATION; PREVALENCE; COUNTRIES; SMOKING; Spirometry; FeNO; German National Cohort; Asthma; COPD |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin > Lehrstuhl für Genetische Epidemiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Mar 2021 07:18 |
| Last Modified: | 30 Mar 2021 07:18 |
| URI: | https://pred.uni-regensburg.de/id/eprint/45083 |
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