Delacher, Michael and Imbusch, Charles D. and Hotz-Wagenblatt, Agnes and Mallm, Jan-Philipp and Bauer, Katharina and Simon, Malte and Riegel, Dania and Rendeiro, Andre F. and Bittner, Sebastian and Sanderink, Lieke and Pant, Asmita and Schmidleithner, Lisa and Braband, Kathrin L. and Echtenachter, Bernd and Fischer, Alexander and Giunchiglia, Valentina and Hoffmann, Petra and Edinger, Matthias and Bock, Christoph and Rehli, Michael and Brors, Benedikt and Schmidl, Christian and Feuerer, Markus (2020) Precursors for Nonlymphoid-Tissue Treg Cells Reside in Secondary Lymphoid Organs and Are Programmed by the Transcription Factor BATF. IMMUNITY, 52 (2). 295-+. ISSN 1074-7613, 1097-4180
Full text not available from this repository. (Request a copy)Abstract
Specialized regulatory T (Treg) cells accumulate and perform homeostatic and regenerative functions in nonlymphoid tissues. Whether common precursors for nonlymphoid-tissue Treg cells exist and how they differentiate remain elusive. Using transcription factor nuclear factor, interleukin 3 regulated (Nfil3) reporter mice and single-cell RNA-sequencing (scRNA-seq), we identified two precursor stages of interleukin 33 (IL-33) receptor ST2-expressing non lymphoid tissue Treg cells, which resided in the spleen and lymph nodes. Global chromatin profiling of nonlymphoid tissue Treg cells and the two precursor stages revealed a stepwise acquisition of chromatin accessibility and reprogramming toward the nonlymphoid-tissue Treg cell phenotype. Mechanistically, we identified and validated the transcription factor Batf as the driver of the molecular tissue program in the precursors. Understanding this tissue development program will help to harness regenerative properties of tissue Treg cells for therapy.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | REGULATORY T-CELLS; DIFFERENTIATION; ACCUMULATION; AUTOIMMUNITY; POPULATION; ALIGNMENT; ELEMENTS; FATE; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Immunologie Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Zentren des Universitätsklinikums Regensburg > Regensburger Centrum für Interventionelle Immunologie (RCI) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Mar 2021 08:21 |
| Last Modified: | 30 Mar 2021 08:21 |
| URI: | https://pred.uni-regensburg.de/id/eprint/45099 |
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