Stokkel, Laura E. and Mehta, Akash M. and Behrendt, Mark A. and de Jong, Jeroen and Bekers, Elise M. and Hendricksen, Kees and Aalbers, Arend G. J. and Kok, Niels F. M. and Meinhardt, Wim and Mertens, Laura S. and van Rhijn, Bas W. G. (2020) Diagnostic Laparoscopy and Abdominal Cytology Reliably Detect Peritoneal Metastases in Patients with Urachal Adenocarcinoma. ANNALS OF SURGICAL ONCOLOGY, 27 (7). pp. 2468-2475. ISSN 1068-9265, 1534-4681
Full text not available from this repository. (Request a copy)Abstract
Background Urachal adenocarcinoma (UrAC) is a rare malignancy that can cause peritoneal metastases (PM). Analogous to other enteric malignancies, selected patients with limited PM of UrAC can be treated by cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC). Objective The aim of this study was to address the value of diagnostic laparoscopy (DLS) and abdominal cytology (ACyt) for the detection and evaluation of the extent of PM in patients with UrAC. Methods A consecutive series of cN0M0 patients with UrAC who underwent DLS with or without ACyt at a tertiary referral center between 2000 and 2018 was assessed. Patients were staged with computed tomography (CT) and/or positron emission tomography (PET)/CT or bone scan. DLS was performed to rule out PM and to evaluate the extent and resectability of PM if seen on imaging. Sensitivity and specificity values were calculated for imaging, DLS, ACyt, and the combination of DLS and ACyt. Results Thirty-two patients with UrAC underwent DLS. ACyt was obtained in 19 patients. Four patients had suspicion of PM on imaging. In the 28 patients who were PM-negative on imaging, DLS and ACyt revealed PM in 6 (21%) patients, of whom 5 had macroscopically visible PM; 1 patient had positive ACyt without visible PM. Sensitivity of combined DLS/ACyt for the detection of PM was 91%, with a specificity of 100%, whereas sensitivity of imaging was 36%. DLS correctly predicted resectability in all patients. Conclusion Combined DLS/ACyt proved an effective tool to detect occult PM and to evaluate the extent of PM to select UrAC patients for possible treatment with CRS/HIPEC.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY; STAGING LAPAROSCOPY; CYTOREDUCTIVE SURGERY; LAVAGE CYTOLOGY; CARCINOMATOSIS; CT; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Mar 2021 08:36 |
| Last Modified: | 30 Mar 2021 08:36 |
| URI: | https://pred.uni-regensburg.de/id/eprint/45115 |
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