Gregoritza, Manuel and Brandl, Ferdinand P. (2015) The Diels-Alder reaction: A powerful tool for the design of drug delivery systems and biomaterials. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 97B. pp. 438-453. ISSN 0939-6411, 1873-3441
Full text not available from this repository. (Request a copy)Abstract
Click reactions have the potential to greatly facilitate the development of drug delivery systems and biomaterials. These reactions proceed under mild conditions, give high yields, and form only inoffensive by-products. The Diels-Alder cycloaddition is one of the click reactions that do not require any metal catalyst; it is one of the most useful reactions in synthetic organic chemistry and material design. Herein, we highlight possible applications of the Diels-Alder reaction in pharmaceutics and biomedical engineering. Particular focus is placed on the synthesis of polymers and dendrimers for drug delivery, the preparation of functionalized surfaces, bioconjugation techniques, and applications of the Diels-Alder reaction in nanotechnology. Moreover, applications of the reaction for the preparation of hydrogels for drug delivery and tissue engineering are reviewed. A general introduction to the Diels-Alder reaction is presented, along with a discussion of potential pitfalls and challenges. At the end of the article, we provide a set of tools that may facilitate the application of the Diels-Alder reaction to solve important pharmaceutical or biomedical problems. (C) 2015 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BLOCK-COPOLYMER MICELLES; CYCLOPENTADIENE TELECHELIC POLYISOBUTYLENE; TETRAZINE-NORBORNENE CHEMISTRY; TRANSFER AGENTS INIFERS; SHAPE-MEMORY POLYMERS; LEWIS-ACID CATALYSIS; CLICK CHEMISTRY; CROSS-LINKING; BIOMEDICAL APPLICATIONS; SURFACE IMMOBILIZATION; Diels-Alder reaction; Click chemistry; Drug delivery; Biomaterials; Polymers; Dendrimers; Surface functionalization; Bioconjugation; Nanoparticles; Hydrogels |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 26 Aug 2020 08:18 |
| Last Modified: | 26 Aug 2020 08:18 |
| URI: | https://pred.uni-regensburg.de/id/eprint/4512 |
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