Aguilar-Perez, Marta and Hellstern, Victoria and AlMatter, Muhammad and Wendl, Christina and Baezner, Hansjoerg and Ganslandt, Oliver and Henkes, Hans (2020) The p48 Flow Modulation Device with Hydrophilic Polymer Coating (HPC) for the Treatment of Acutely Ruptured Aneurysms: Early Clinical Experience Using Single Antiplatelet Therapy. CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY, 43 (5). pp. 740-748. ISSN 0174-1551, 1432-086X
Full text not available from this repository. (Request a copy)Abstract
Background Flow diversion (FD) remains a potential treatment option following aneurysmal subarachnoid hemorrhage (aSAH) when standard options may not be feasible. However, it should not be considered a first-line treatment due to the need for dual antiplatelet therapy (DAPT). The hydrophilic polymer coating on the p48MW flow diverter (HPC, phenox) is a surface modification that inhibits platelet adhesion. This study aims to report on our early single-center experience using the p48MW HPC (phenox) flow diverter with single antiplatelet therapy (SAPT) following an aSAH. Materials and Methods We retrospectively identified all patients who had been treated with the p48MW HPC for aSAH under SAPT. All patients treated within 30 days following an aSAH were included. Any occurrence of thromboembolic and hemorrhagic complications was recorded alongside angiographic and clinical follow-up details. Results Eight patients were identified. The mean interval between aSAH and FD was 6 days. Of the eight ruptured aneurysms, one was blister-like, one saccular, one mycotic, and the remaining five were dissecting aneurysms. Intraprocedural transient thrombus formation was observed in four patients (50%). Stent thrombosis was observed in one patient (12.5%) on day 3 with spontaneous recanalization after being switched onto DAPT. None of the aneurysms rebled after treatment. Two patients died due to cerebral vasospasm. Complete aneurysm occlusion had been achieved in all but one patient at angiographic follow-up (average 6 months). Conclusions This small series highlights the possibility and limitations of using the p48MW HPC with SAPT in ruptured aneurysms. Randomized trials with longer follow-up in larger cohorts are underway.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INTRACRANIAL ANEURYSMS; ENDOVASCULAR TREATMENT; Ruptured aneurysm; Blister-like aneurysm; Dissecting aneurysm; Aneurysmal subarachnoid hemorrhage; Flow diverter; Surface modification; HPC; p48MW HPC; Single antiplatelet therapy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Röntgendiagnostik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Mar 2021 11:16 |
| Last Modified: | 30 Mar 2021 11:16 |
| URI: | https://pred.uni-regensburg.de/id/eprint/45144 |
Actions (login required)
 |
View Item |
