Mumuni, Momoh A. and Calister, Ugwu E. and Aminu, Nafiu and Franklin, Kenechukwu C. and Oluseun, Adedokun Musiliu and Usman, Mohammed and Abdulmumuni, Barikisu and James, Oyeniyi Y. and Ofokansi, Kenneth C. and Anthony, Attama A. and Ibezim, Emmanuel C. and Diaz Diaz, David (2020) Mucin-Grafted Polyethylene Glycol Microparticles Enable Oral Insulin Delivery for Improving Diabetic Treatment. APPLIED SCIENCES-BASEL, 10 (8): 2649. ISSN , 2076-3417
Full text not available from this repository. (Request a copy)Abstract
In this study, different ratios of mucin-grafted polyethylene-glycol-based microparticles were prepared and evaluated both in vitro and in vivo as carriers for the oral delivery of insulin. Characterization measurements showed that the insulin-loaded microparticles display irregular porosity and shape. The encapsulation efficiency and loading capacity of insulin were >82% and 18%, respectively. The release of insulin varied between 68% and 92% depending on the microparticle formulation. In particular, orally administered insulin-loaded microparticles resulted in a significant fall of blood glucose levels, as compared to insulin solution. Subcutaneous administration showed a faster, albeit not sustained, glucose fall within a short time as compared to the polymeric microparticle-based formulations. These results indicate the possible oral delivery of insulin using this combination of polymers.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | IN-VITRO; CELLULAR UPTAKE; NANOPARTICLES; MICROSPHERES; FORMULATION; PEGYLATION; SYSTEM; SIZE; insulin; mucin; polyethylene glycol; microparticles; toxicology |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie > Arbeitskreis Prof. Dr. David Díaz Díaz |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Mar 2021 10:19 |
| Last Modified: | 30 Mar 2021 10:19 |
| URI: | https://pred.uni-regensburg.de/id/eprint/45160 |
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