Seliger, Corinna and Genbrugge, Els and Gorlia, Thierry and Chinot, Olivier and Stupp, Roger and Nabors, Burt and Weller, Michael and Hau, Peter (2020) Use of metformin and outcome of patients with newly diagnosed glioblastoma: Pooled analysis. INTERNATIONAL JOURNAL OF CANCER, 146 (3). pp. 803-809. ISSN 0020-7136, 1097-0215
Full text not available from this repository. (Request a copy)Abstract
Metformin has been linked to improve survival of patients with various cancers. There is little information on survival of glioblastoma patients after use of metformin. We assessed the association between metformin use and survival in a pooled analysis of patient data from 1,731 individuals from the randomized AVAglio, CENTRIC and CORE trials. We performed multivariate Cox analyses for overall survival (OS) and progression-free survival (PFS) comparing patients' use of metformin at baseline and/or during concomitant radiochemotherapy (TMZ/RT). Further exploratory analyses investigated the effect of metformin with a history of diabetes and nonfasting glucose levels in relation to OS or PFS of glioblastoma patients. Metformin alone or in any combination was not significantly associated with OS or PFS (at baseline, hazard ratio [HR] for OS = 0.87; 95% confidence interval [CI] = 0.65-1.16; HR for PFS = 0.84; 95% CI = 0.64-1.10; during TMZ/RT HR for OS = 0.97; 95% CI = 0.68-1.38; HR for PFS = 1.02; 95% CI = 0.74-1.41). We found a statistically nonsignificant association of metformin monotherapy with glioblastoma survival at baseline (HR for OS = 0.68; 95% CI = 0.42-1.10; HR for PFS = 0.57; 95% CI = 0.36-0.91), but not during the TMZ/RT period (HR for OS = 0.90; 95% CI = 0.51-1.56; HR for PFS = 1.05; 95% CI = 0.64-1.73). Diabetes mellitus or increased nonfasting glucose levels were not associated with a difference in OS or PFS in our selected study population. Metformin did not prolong survival of patients with newly diagnosed glioblastoma in our analysis. Additional studies may identify patients with specific tumor characteristics that are associated with potential benefit from treatment with metformin, possibly due to metabolic vulnerabilities.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | STANDARD TREATMENT; STEM-CELLS; OPEN-LABEL; CANCER; INHIBITION; SURVIVAL; GROWTH; TEMOZOLOMIDE; INVASION; glioblastoma; metformin; overall survival; drug repurposing |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Mar 2021 10:20 |
| Last Modified: | 30 Mar 2021 10:20 |
| URI: | https://pred.uni-regensburg.de/id/eprint/45163 |
Actions (login required)
 |
View Item |
