Blazquez, R. and Sparrer, D. and Wendl, C. and Evert, M. and Riemenschneider, M. J. and Krahn, M. P. and Erez, N. and Proescholdt, M. and Pukrop, T. (2020) The macro-metastasis/organ parenchyma interface (MMPI) - A hitherto unnoticed area. SEMINARS IN CANCER BIOLOGY, 60. pp. 324-333. ISSN 1044-579X, 1096-3650
Full text not available from this repository. (Request a copy)Abstract
The macro-metastasis/organ parenchyma interface (MMPI) was previously considered an inert anatomical border which sharply separates the affected organ parenchyma from the macro-metastatic tissue. Recently, infiltrative growth of macro-metastases from various primary tumors was described in the brain, liver and lung, with significant impact on survival. Strikingly, the MMPI patterns differed between entities, so that at least nine different patterns were described. The MMPI patterns could be further classified into three major groups: displacing, epithelial and diffuse infiltrating. Additionally, macro-metastases are a source of further tumor cell dissemination in the affected organ; and these infra-organ metastatic dissemination tracks starting from the MMPI also vary depending on the anatomical structures of the colonized organ and influence disease outcome. In spite of their relevance, MMPIs and organ-specific dissemination tracks are still largely overlooked by many clinicians, pathologists and/or researchers. In this review, we aim to address this important issue and enhance our current understanding of the different MMPI patterns and dissemination tracks in the brain, liver and lung.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BREAST-CANCER PATIENTS; LIVER METASTASES; GROWTH-PATTERNS; SUPRAMARGINAL RESECTION; COLORECTAL-CANCER; BRAIN METASTASES; SURVIVAL; INVASION; LUNG; CARCINOMAS; Dissemination; Displacing; Infiltration; Interface; Macro-metastasis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Lehrstuhl für Neurochirurgie Medicine > Abteilung für Neuropathologie Medicine > Lehrstuhl für Pathologie Medicine > Lehrstuhl für Röntgendiagnostik |
| Depositing User: | Petra Gürster |
| Date Deposited: | 08 Apr 2021 07:25 |
| Last Modified: | 08 Apr 2021 07:25 |
| URI: | https://pred.uni-regensburg.de/id/eprint/45185 |
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