Metterlein, Thomas and Schuster, Frank and Hager, Martin and Roewer, Norbert and Anetseder, Martin (2015) Metabolic effects as a cause of myotoxic effects of fluoroquinolones. INDIAN JOURNAL OF PHARMACOLOGY, 47 (6). pp. 616-619. ISSN 0253-7613, 1998-3751
Full text not available from this repository. (Request a copy)Abstract
Objectives: To investigate if fluoroquinolones (FQs) influence skeletal muscle metabolism of healthy and malignant hyperthermia susceptible (MHS) pigs. Materials and Methods: After approval from of the Animal Care Committee, 10 MHS pigs, and 6 MHS pigs were anesthetized with hemodynamic and systemic metabolic monitoring. Microdialysis catheters were placed intramuscularly. After equilibration, levofloxacin and ciprofloxacin were injected as a rapid bolus and continuous infusions. Lactate was measured in the dialysate and statistically analyzed was done (Wilcoxon-test; U-test; P < 0.05). Results: There were no differences in age, weight, and baseline lactate levels between the groups. Both applications of levofloxacin- and ciprofloxacin-induced an increase of local lactate levels in healthy and MHS pigs. No difference between the two groups was observed. Conclusion: FQs influence skeletal muscle metabolism. Myotoxic effects of FQs can, therefore, be explained by an influence on the cellular energy balance.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MALIGNANT HYPERTHERMIA SUSCEPTIBILITY; INTRAMUSCULAR INJECTION; IN-VITRO; CIPROFLOXACIN; RHABDOMYOLYSIS; LEVOFLOXACIN; TISSUE; SPECTROSCOPY; INDIVIDUALS; DIAGNOSIS; Fluoroquinolones; malignant hyperthermia; metabolism; myotoxicity |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 May 2019 08:49 |
| Last Modified: | 06 May 2019 08:49 |
| URI: | https://pred.uni-regensburg.de/id/eprint/4520 |
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