Anssar, Tareq M. and Leitzmann, Michael F. and Linker, Ralf A. and Meier, Christoph and Becker, Claudia and Jick, Susan and Sahm, Katharina and Platten, Michael and Hau, Peter and Seliger, Corinna (2020) Autoimmune diseases and immunosuppressive therapy in relation to the risk of glioma. CANCER MEDICINE, 9 (3). pp. 1263-1275. ISSN 2045-7634,
Full text not available from this repository. (Request a copy)Abstract
Effectors from the immune system can modulate the course and possibly the early development of gliomas. We, therefore, hypothesized that autoimmune diseases associated with increased immune-surveillance may also modulate the risk of human glioma. To test this hypothesis, we used data from the well-validated Clinical Practice Research Datalink (CPRD) GOLD from the UK to analyze the association of immune-related disorders or use of immunosuppressive drugs and the risk of glioma. We identified 3112 incident glioma cases diagnosed between 1995 and 2017. We randomly selected up to 10 controls, matching them to glioma cases on age, sex, index date, general practice, and number of years of active history in the database prior to the index date. We performed conditional logistic regression analyses to estimate Odds Ratios (ORs) of glioma among those exposed to allergies, autoimmune diseases, and immunosuppressive drugs. Overall, we found no materially altered association between a history of any autoimmune disease (OR 0.98, 95% CI 0.86-1.11), allergy (OR 0.97, 95% CI 0.89-1.05), or use of immunosuppressive drugs and the risk of glioma. However, subgroup analyses among younger patients found a statistically significant increased risk of glioma in patients with a history of inflammatory bowel disease (IBD) (OR 2.59, 95% CI 1.31-5.12). There was also an inverse association between asthma and risk of glioma in patients with longer survival (OR 0.73, 95% CI 0.58-0.91) and between long-term duration diabetes and risk of glioma (OR 0.71, 95% CI 0.53-0.96).
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | REGULATORY T-CELLS; BRAIN-TUMORS; ALLERGIC CONDITIONS; TRANSPLANT RECIPIENTS; IMMUNOGLOBULIN-E; IGE LEVELS; CANCER; GLIOBLASTOMA; MENINGIOMA; MICROBIOTA; autoimmune diseases; glioma; immunosuppressive therapies |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 31 Mar 2021 08:09 |
| Last Modified: | 31 Mar 2021 08:09 |
| URI: | https://pred.uni-regensburg.de/id/eprint/45277 |
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