Weinbender, Thomas and Hofmann, Martin and Reiser, Oliver (2020) Functional changes of biomolecules and organocatalysts as a probe for pressure effects in solution. BIOPHYSICAL CHEMISTRY, 257: 106280. ISSN 0301-4622, 1873-4200
Full text not available from this repository. (Request a copy)Abstract
High pressure acts as a mild and non-destructive activation mode for chemical reactions. However, in the context of organo-/biocatalysis, high pressure activation, has not been investigated systematically, although there are significant benefits such as rate acceleration, increased selectivity and the possibility of suppressing side product formation. The influence of hydrostatic pressure in solution on the catalytic performance of enzymes and small molecule organocatalysts such as amino acids, peptides, amines, cinchona alkaloids and thioureas is evaluated in this review, taking reactivity and selectivity as a probe to identify pressure effects on biomolecules.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CONJUGATE ADDITION-REACTIONS; 1,3-DIPOLAR CYCLOADDITION REACTION; QUATERNARY STEREOGENIC CENTERS; CATALYZED COUPLING REACTIONS; DIELS-ALDER REACTIONS; 1,4-ADDITION REACTIONS; ORGANIC-REACTIONS; REACTION VOLUMES; ALDOL REACTION; ACTIVATION; High pressure; Organocatalysis; Biomolecules; High hydrostatic pressure; Asymmetric catalysis; High pressure activation |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Oliver Reiser |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 31 Mar 2021 08:21 |
| Last Modified: | 31 Mar 2021 08:21 |
| URI: | https://pred.uni-regensburg.de/id/eprint/45280 |
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