Lazzarotto, Tiziana and Blazquez-Gamero, Daniel and Delforge, Marie-Luce and Foulon, Ina and Luck, Suzanne and Modrow, Susanne and Leruez-Ville, Marianne (2020) Congenital Cytomegalovirus Infection: A Narrative Review of the Issues in Screening and Management From a Panel of European Experts. FRONTIERS IN PEDIATRICS, 8: 13. ISSN 2296-2360
Full text not available from this repository. (Request a copy)Abstract
Maternal primary and non-primary cytomegalovirus (CMV) infection during pregnancy can result in in utero transmission to the developing fetus. Congenital CMV (cCMV) can result in significant morbidity, mortality or long-term sequelae, including sensorineural hearing loss, the most common sequela. As a leading cause of congenital infections worldwide, cCMV infection meets many of the criteria for screening. However, currently there are no universal programs that offer maternal or neonatal screening to identify infected mothers and infants, no vaccines to prevent infection, and no efficacious and safe therapies available for the treatment of maternal or fetal CMV infection. Data has shown that there are several maternal and neonatal screening strategies, and diagnostic methodologies, that allow the identification of those at risk of developing sequelae and adequately detect cCMV. Nevertheless, many questions remain unanswered in this field. Well-designed clinical trials to address several facets of CMV treatment (in pregnant women, CMV-infected fetuses and both symptomatic and asymptomatic neonates and children) are required. Prevention (vaccines), biology and transmission factors associated with non-primary CMV, and the cost-effectiveness of universal screening, all demand further exploration to fully realize the ultimate goal of preventing cCMV. In the meantime, prevention of primary infection during pregnancy should be championed to all by means of hygiene education.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | POLYMERASE-CHAIN-REACTION; PRENATAL-DIAGNOSIS; PREGNANT-WOMEN; CMV INFECTION; COST-EFFECTIVENESS; HEARING; RISK; PREVENTION; BLOOD; VALGANCICLOVIR; cytomegalovirus; neonatal screening; prenatal diagnosis; clinical laboratory techniques; congenital CMV; pregnancy; maternal screening |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Petra Gürster |
| Date Deposited: | 25 Mar 2021 06:55 |
| Last Modified: | 25 Mar 2021 06:55 |
| URI: | https://pred.uni-regensburg.de/id/eprint/45293 |
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