Aegerter, Helena and Kulikauskaite, Justina and Crotta, Stefania and Patel, Harshil and Kelly, Gavin and Hessel, Edith M. and Mack, Matthias and Beinke, Soren and Wack, Andreas (2020) Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection. NATURE IMMUNOLOGY, 21 (2). 145-+. ISSN 1529-2908, 1529-2916
Full text not available from this repository. (Request a copy)Abstract
Respiratory infections occur throughout life but how this shapes the lung immune system through time is unclear. Wack and colleagues show that a previous influenza infection recruits monocytes to the lung, which then assume an alveolar macrophage-like phenotype and mediate long-term antibacterial protection. Despite the prevalence and clinical importance of influenza, its long-term effect on lung immunity is unclear. Here we describe that following viral clearance and clinical recovery, at 1 month after infection with influenza, mice are better protected from Streptococcus pneumoniae infection due to a population of monocyte-derived alveolar macrophages (AMs) that produce increased interleukin-6. Influenza-induced monocyte-derived AMs have a surface phenotype similar to resident AMs but display a unique functional, transcriptional and epigenetic profile that is distinct from resident AMs. In contrast, influenza-experienced resident AMs remain largely similar to naive AMs. Thus, influenza changes the composition of the AM population to provide prolonged antibacterial protection. Monocyte-derived AMs persist over time but lose their protective profile. Our results help to understand how transient respiratory infections, a common occurrence in human life, can constantly alter lung immunity by contributing monocyte-derived, recruited cells to the AM population.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GM-CSF; FETAL MONOCYTES; TISSUE; CELLS; LIFE; REPLACEMENT; DEVELOP; ORIGIN; NICHE; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Nephrologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Apr 2021 07:27 |
| Last Modified: | 09 Apr 2021 07:27 |
| URI: | https://pred.uni-regensburg.de/id/eprint/45350 |
Actions (login required)
 |
View Item |
