Meisinger, Christa and Linseisen, Jakob and Leitzmann, Michael and Baurecht, Hansjoerg and Baumeister, Sebastian Edgar (2020) Association of physical activity and sedentary behavior with type 2 diabetes and glycemic traits: a two-sample Mendelian randomization study. BMJ OPEN DIABETES RESEARCH & CARE, 8 (2): e001896. ISSN , 2052-4897
Full text not available from this repository. (Request a copy)Abstract
Introduction Observational studies suggest that physical activity lowers and sedentary behavior increases the risk of type 2 diabetes. Despite of some supportive trial data for physical activity, it is largely unresolved whether these relations are causal or due to bias. Objective We investigated the associations between accelerometer-based physical activity and sedentary behavior with type 2 diabetes and several glycemic traits using two-sample Mendelian randomization analysis. Research design and methods Single nucleotide polymorphisms (SNPs) associated at p<5x10(-8) with accelerometer-based physical activity average accelerations, vigorous physical activity (fraction of accelerations >425 milligravities), and sedentary behavior (metabolic equivalent task <= 1.5) in a genome-wide analysis of the UK Biobank served as instrumental variables. Outcomes Type 2 diabetes, hemoglobin A1c (HbA1c), fasting glucose, homeostasis model assessment of beta-cell function (HOMA-B), and homeostasis model assessment of insulin resistance (HOMA-IR). Results Physical activity and sedentary behavior were unrelated to type 2 diabetes, HbA1c, fasting glucose, HOMA-B, and HOMA-IR. The inverse variance weighted ORs per SD increment for the association between average accelerations and vigorous physical activity with type 2 diabetes were 1.00 (95% CI 0.94 to 1.07, p=0.948) and 0.83 (95% CI 0.56 to 1.23, p=0.357), respectively. These results were confirmed by sensitivity analyses using alternative MR-methods to test the robustness of our findings. Conclusions Based on these results, genetically predicted objectively measured average or vigorous physical activity and sedentary behavior is not associated with type 2 diabetes risk or with glycemic traits in the general population. Further research is required to deepen the understanding of the biological pathways of physical activity.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INSULIN-RESISTANCE; FASTING GLUCOSE; RISK; INTERVENTIONS; SMOKING; HBA1C; diabetes mellitus; type 2; physical fitness; blood glucose; glycated hemoglobin A |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Apr 2021 07:28 |
| Last Modified: | 06 Apr 2021 07:28 |
| URI: | https://pred.uni-regensburg.de/id/eprint/45385 |
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